Lipoic acid based core cross-linked micelles for multivalent platforms: design, synthesis and application in bio-imaging and drug delivery

被引：18

作者：

Huang, Jingsheng ^{[1
]}

Wu, Fang ^{[1
]}

Yu, Yunlong ^{[2
]}

Huang, Haolong ^{[2
]}

Zhang, Shiyong ^{[1
,2
]}

You, Jingsong ^{[1
]}

机构：

[1] Sichuan Univ, Coll Pharm, 29 Wangjiang Rd, Chengdu 610064, Peoples R China

[2] Sichuan Univ, Natl Engn Res Ctr Biomat, 29 Wangjiang Rd, Chengdu 610064, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 22期

基金：

中国国家自然科学基金;

关键词：

BIOMEDICAL APPLICATIONS; BREAST-CANCER; NANOPARTICLES; NANOCARRIERS; THERAPY; LIGANDS; DOXORUBICIN; DENDRIMERS; SYSTEMS;

D O I：

10.1039/c7ob00927e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water. The presence of numerous disulfides accumulated in the core makes the micelles readily cross-linked to achieve the establishment of core cross-linked micelles (CCMs). Thanks to the inherent biocompatibility, the resulting lipoic acid based CCMs (LA-CCMs) are good multivalent platforms for biomedical applications.

引用

页码：4798 / 4802

页数：5

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