Therapeutic potential of interleukin-2 in autoimmune diseases

被引：52

作者：

Yuan, Yeshuang ^{[1
]}

Kolios, Antonios G. A. ^{[2
,3
]}

Liu, Yudong ^{[1
]}

Zhang, Bo ^{[4
]}

Li, Hao ^{[2
]}

Tsokos, George C. ^{[2
]}

Zhang, Xuan ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch,Dept Rheumatol,Beijing Hosp, Clin Immunol Ctr,Inst Geriatr Med,Natl Ctr Geront, Beijing 100730, Peoples R China

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA

[3] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland

[4] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Diqeases, Beijing 100730, Peoples R China

来源：

TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 07期

基金：

中国国家自然科学基金;

关键词：

REGULATORY T-CELLS; LOW-DOSE INTERLEUKIN-2; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RESPONSE ELEMENT MODULATOR; RECOMBINANT INTERLEUKIN-2; DOUBLE-BLIND; MEDIATED SUPPRESSION; IMMUNE PRIVILEGE; IL-2; RECEPTOR; CUTTING EDGE;

D O I：

10.1016/j.molmed.2022.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autoimmune diseases are characterized by dysregulation and aberrant activation of cells in the immune system. Therefore, restoration of the immune balance represents a promising therapeutic target in autoimmune diseases. Interleukin-2 (IL-2) can promote the expansion and differentiation of different immune cell subsets dose-dependently. At high doses, IL-2 can promote the differentiation and expansion of effector and memory T cells, whereas at low doses, IL-2 can promote the differentiation, survival, and function of regulatory T (T-reg) cells, a CD4(+) T cell subset that is essential for the maintenance of immune homeostasis and immune tolerance. Therefore, IL-2 exerts immunostimulatory and immunosuppressive effects in autoimmune diseases. The immunoregulatory role of low-dose IL-2 has sparked excitement for the therapeutic exploration of modulating the IL-2-Treg axis in the context of autoimmune diseases. In this review, we discuss recent advances in the therapeutic potential of IL-2 or IL-2-derived molecules in the treatment of autoimmune diseases.

引用

页码：596 / 612

页数：17

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