Amyotrophic lateral sclerosis and Alzheimer's disease -: clinical and neuropathological considerations in two cases

被引：14
作者：
Rusina, R.
Sheardova, K.
Rektorova, I.
Ridzon, P.
Kulist'ak, P.
Matej, R.
机构：
[1] Thomayer Teaching Hosp, Inst Postgrad Med Educ, Dept Neurol, Prague, Czech Republic
[2] Masaryk Univ, St Annes Hosp, Dept Neurol, Brno, Czech Republic
[3] Thomayer Teaching Hosp, Inst Postgrad Med Educ, Dept Pathol, Prague, Czech Republic
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2007年 / 14卷 / 07期
关键词：
Alzheimer's disease; amyotrophic lateral sclerosis; dementia; senile plaques; ubiquitin inclusions;
D O I：
10.1111/j.1468-1331.2007.01759.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Amyotrophic lateral sclerosis (ALS) may be accompanied by cognitive impairment; when present, it is mainly in the form of frontotemporal impairment. We report on two cases with clinically defined ALS that subsequently developed dementia. Neuropathological examination showed not only the typical neuropathological hallmarks characteristic of ALS but, surprisingly, also showed neurofibrillary tangles and neuritic plaques in sufficient numbers to fulfill the diagnostic criteria of definite Alzheimer's disease.
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收藏
页码：815 / 818
页数：4
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