Severe Thrombocytopenia Caused by Vancomycin in the Intensive Care Unit: A Case Report

被引：2

作者：

Li, Xiao-xiao ^{[1
,2
,3
,4
]}

Wang, Guan-ru ^{[1
,2
,3
,4
]}

Li, Chao ^{[1
,2
]}

He, Na ^{[1
,2
,3
,4
]}

Yao, Peng ^{[3
,4
]}

Cheng, Yin-chu ^{[1
,2
]}

Wang, Chu-hui ^{[1
,2
,3
,4
]}

Ge, Qing-gang ^{[1
,2
]}

Yi, Min ^{[1
,2
]}

Wang, Zong-yu ^{[1
,2
]}

Shi, Lu-wen ^{[3
,4
]}

Zhao, Rong-sheng ^{[1
,2
,3
,4
]}

机构：

[1] Peking Univ Third Hosp, Dept Pharm, Beijing, Peoples R China

[2] Peking Univ Third Hosp, Dept Intens Care Unit, Beijing, Peoples R China

[3] Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm, Beijing, Peoples R China

[4] Peking Univ, Sch Pharmaceut Sci, Clin Pharm, Beijing, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

vancomycin; thrombocytopenia; adverse drug reaction; critically illness; case report; GUIDELINES; SEPSIS;

D O I：

10.3389/fmed.2022.829267

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors and various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case of severe thrombocytopenia during intensive care unit (ICU) hospitalization that was likely to be associated with vancomycin. By revealing the process of identifying this case of DITP and reviewing relevant clinical studies, a risk alert of vancomycin-related severe hematotoxicity should be considered.

引用

页数：7

共 22 条

[1] A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia [J].

Arnold, D. M. ;

Kukaswadia, S. ;

Nazi, I. ;

Esmail, A. ;

Dewar, L. ;

Smith, J. W. ;

Warkentin, T. E. ;

Kelton, J. G. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (01) :169-176

[2] EVALUATION OF THE CONSISTENCY OF ACUTE PHYSIOLOGY AND CHRONIC HEALTH EVALUATION (APACHE-II) SCORING IN A SURGICAL INTENSIVE-CARE UNIT [J].

BERGER, MM ;

MARAZZI, A ;

FREEMAN, J ;

CHIOLERO, R .

CRITICAL CARE MEDICINE, 1992, 20 (12) :1681-1687

[3]

Chinese Society of Internal Medicine Chinese Medical Association, 2020, Zhonghua Nei Ke Za Zhi, V59, P498, DOI 10.3760/cma.j.cn112138-20200424-00419

[4] Monitoring sedation status over time in ICU patients - Reliability and validity of the Richmond Agitation-Sedation Scale (RASS) [J].

Ely, EW ;

Truman, B ;

Shintani, A ;

Thomason, JWW ;

Wheeler, AP ;

Gordon, S ;

Francis, J ;

Speroff, T ;

Gautam, S ;

Margolin, R ;

Sessler, CN ;

Dittus, RS ;

Bernard, GR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (22) :2983-2991

[5]

George James N, 2009, Hematology Am Soc Hematol Educ Program, P153, DOI 10.1182/asheducation-2009.1.153

[6] Hematologic effects of linezolid: Summary of clinical experience [J].

Gerson, SL ;

Kaplan, SL ;

Bruss, JB ;

Le, V ;

Arellano, FM ;

Hafkin, B ;

Kuter, DJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (08) :2723-2726

[7] Evidence-based Guideline for Therapeutic Drug Monitoring of Vancomycin: 2020 Update by the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society [J].

He, Na ;

Su, Shan ;

Ye, Zhikang ;

Du, Guanhua ;

He, Bei ;

Li, Dakui ;

Liu, Youning ;

Yang, Kehu ;

Zhang, Xianglin ;

Zhang, Yingyuan ;

Chen, Xiao ;

Chen, Yaolong ;

Chen, Zhigang ;

Dong, Yalin ;

Du, Guang ;

Gu, Jian ;

Guo, Daihong ;

Guo, Ruichen ;

Hu, Xin ;

Jiao, Zheng ;

Li, Huande ;

Liu, Gaolin ;

Li, Zhiping ;

Lv, Yuan ;

Lu, Wei ;

Miao, Liyan ;

Qu, Jieming ;

Sun, Tieying ;

Tong, Rongsheng ;

Wang, Li ;

Wang, Minggui ;

Wang, Rui ;

Wen, Aidong ;

Wu, Jiuhong ;

Wu, Xin'an ;

Xu, Yingchun ;

Yang, Yong ;

Yang, Fan ;

Zhan, Siyan ;

Zhang, Bikui ;

Zhang, Chao ;

Zhang, Huizhi ;

Zhang, Jie ;

Zhang, Jing ;

Zhang, Jun ;

Zhang, Wenting ;

Zhao, Libo ;

Zhao, Limei ;

Zhao, Rongsheng ;

Zhao, Wei .

CLINICAL INFECTIOUS DISEASES, 2020, 71 :S363-S371

[8] Vancomycin-induced thrombocytopenia: A challenge and rechallenge [J].

Howard, CE ;

Adams, LA ;

Admire, JL ;

Chu, MA ;

Alred, GL .

ANNALS OF PHARMACOTHERAPY, 1997, 31 (03) :315-318

[9] Detection of drug-dependent, platelet-reactive antibodies by solid-phase red cell adherence assays [J].

Leach, MF ;

Cooper, LK ;

AuBuchon, JP .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 97 (04) :755-761

[10]

Marinho Daniel Savignon, 2011, BMC Res Notes, V4, P236

← 1 2 3 →