Radiofrequency Ablation to Treat Loco-Regional Recurrence of Well-Differentiated Thyroid Carcinoma

被引:75
作者
Lee, Sun Jin [1 ]
Jung, So Lyung [2 ]
Kim, Bum Soo [2 ]
Ahn, Kook Jin [2 ]
Choi, Hyun Seok [2 ]
Lim, Dong Jun [3 ]
Kim, Min Hee [3 ]
Bae, Ja Seong [4 ]
Kim, Min Sik [5 ]
Jung, Chan Kwon [6 ]
Chong, Se Min [1 ]
机构
[1] Chung Ang Univ Hosp, Dept Radiol, Seoul 156755, South Korea
[2] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Radiol, Seoul 137701, South Korea
[3] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Internal Med, Seoul 137701, South Korea
[4] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Surg, Seoul 137701, South Korea
[5] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Otolaryngol, Seoul 137701, South Korea
[6] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Clin Pathol, Seoul 137701, South Korea
关键词
Radiofrequency ablation; Recurrent thyroid cancer; Efficacy; Thyroid; Ultrasound; PERCUTANEOUS ETHANOL INJECTION; LASER-ABLATION; PAPILLARY; METASTASES; CANCER;
D O I
10.3348/kjr.2014.15.6.817
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: To evaluate the efficacy of radiofrequency ablation (RFA) in the treatment of Loco-regional, recurrent, and well-differentiated thyroid carcinoma. Materials and Methods: Thirty-five recurrent well-differentiated thyroid carcinomas (RTC) in 32 patients were treated with RFA, between March 2008 and October 2011. RTCs were detected by regular follow-up ultrasound and confirmed by biopsy. All patients had fewer than 3 RTCs in the neck and were at high surgical risk or refused to undergo repeated surgery. Average number of RFA sessions were 1.3 (range 1-3). Post-RFA biopsy and ultrasound were performed. The mean follow-up period was 30 months. Pre- and post-RFA serum thyroglobulin values were evaluated. Results: Thirty-one patients with 33 RTCs were treated with RFA only, whereas 1 patient with 2 RTCs was treated with RFA followed by surgery. At the last follow-up ultrasound, 31 (94%) of the 33 RTCs treated with RFA alone completely disappeared and the remaining 2 (6%) RTCs showed decreased volume. The largest diameter and volume of the 33 RTCs were markedly decreased by 93.2% (from 8.1 +/- 3.4 mm to 0.6 +/- 1.8 mm, p < 0.001) and 96.4% (from 173.9 +/- 198.7 mm(3) to 6.2 +/- 27.9 mm(3), p < 0.001), respectively. Twenty of the 21 RTCs evaluated with post-RFA biopsies (95%) were negative for malignancy. One (5%) showed remaining tumor that was removed surgically. The serum thyroglobulin was decreased in 19 of 26 patients (73%). Voice change developed immediately after RFA in 6 patients (19%) and was spontaneously recovered in 5 patients (83%). Conclusion: Radiofrequency ablation can be effective in treating Loco-regional, recurrent, and well-differentiated thyroid carcinoma in patients at high surgical risk.
引用
收藏
页码:817 / 826
页数:10
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