Effectiveness and acceptability of vitamin E and low-dose aspirin, alone or in combination, on Norplant-induced prolonged bleeding

被引：22

作者：

d'Arcangues, C ^{[1
]}

Piaggio, G ^{[1
]}

Brache, V ^{[1
]}

Aissa, RB ^{[1
]}

Hazelden, C ^{[1
]}

Massai, R ^{[1
]}

Pinol, A ^{[1
]}

Subakir, SB ^{[1
]}

Su-juan, G ^{[1
]}

机构：

[1] World Hlth Org, Special Programme Res, CH-1211 Geneva, Switzerland

来源：

CONTRACEPTION | 2004年 / 70卷 / 06期

关键词：

Norplant; vitamin E; aspirin; vaginal bleeding pattern; acceptability;

D O I：

10.1016/j.contraception.2004.05.012

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A study (ISRCTN 77665712) was undertaken to test the effectiveness and the acceptability of vitamin E and low-dose aspirin, alone or in combination, as treatment for prolonged vaginal bleeding induced by Norplant. A total of 486 Norplant users who were requesting treatment for bleeding lasting longer than 7 days were enrolled in five centers: Beijing, China; Jakarta, Indonesia; Santiago, Chile; Santo Domingo, Dominican Republic; and Tunis, Tunisia. They were randomized to one of four different 10-day oral treatments: 200 mg vitamin E daily, 80 mg aspirin daily, both or a placebo. Treatment packs were designed to ensure blinding of both the subjects and the clinical staff. Neither vitamin E nor low-dose aspirin nor their combination was found to have any effect on reducing the length of the bleeding episode for which treatment was taken or on the vaginal bleeding patterns these women experienced during the year of follow-up. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：451 / 462

页数：12

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