HIV-Selectest Enzyme Immunoassay and Rapid Test: Ability To Detect Seroconversion following HIV-1 Infection

被引：7

作者：

Khurana, Surender ^{[1
]}

Norris, Philip J. ^{[2
,3
]}

Busch, Michael P. ^{[2
,3
]}

Haynes, Barton F. ^{[4
]}

Park, Susan ^{[1
]}

Sasono, Pretty ^{[1
]}

Mlisana, Koleka ^{[5
]}

Salim, Abdool Karim ^{[5
]}

Hecht, Frederick M. ^{[3
]}

Mulenga, Joseph ^{[6
,7
]}

Chomba, Elwyn ^{[7
]}

Hunter, Eric ^{[8
]}

Allen, Susan ^{[9
]}

Nemo, George ^{[10
]}

Rodriguez-Chavez, Isaac R. ^{[11
]}

Margolick, Joseph B. ^{[13
]}

Golding, Hana ^{[1
]}

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Div Viral Prod, Bethesda, MD 20892 USA

[2] Blood Syst Res Inst, San Francisco, CA 94118 USA

[3] Univ Calif San Francisco, San Francisco, CA 94118 USA

[4] Duke Human Vaccine Inst, Durham, NC 27710 USA

[5] Univ KwaZulu Natal, Ctr AIDS Programme Res S Africa, ZA-4013 Durban, South Africa

[6] ZEHRP, Lusaka, Zambia

[7] Zambia Blood Transfus Serv, Lusaka, Zambia

[8] Emory Vaccine Res Ctr, Atlanta, GA 30329 USA

[9] Emory Univ, Sch Publ Hlth, Atlanta, GA 30322 USA

[10] NHLBI, NIH, Bethesda, MD 20817 USA

[11] Natl Inst Dent & Craniofacial Res, AIDS & Immunosuppress Program, NIH, Bethesda, MD 20892 USA

[12] Suny Downstate Med Ctr, Brooklyn, NY 11203 USA

[13] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; VACCINE-GENERATED ANTIBODIES; DIFFERENTIAL-DIAGNOSIS; ANTIRETROVIRAL THERAPY; RNA LEVELS; PLASMA; RESPONSES; VIREMIA; FACE;

D O I：

10.1128/JCM.01573-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-Selectest is a serodiagnostic enzyme immunoassay (EIA), containing p6 and gp41 peptides, designed to differentiate between vaccine-induced antibodies and true infections. A rapid test version of the HIV-Selectest was developed. Both assays detected HIV antibodies in men and women within 2 to 4 weeks of infection, with sensitivity similar to third-generation EIAs.

引用

页码：281 / 285

页数：5

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