Enhanced osteogenic activity of poly ether ether ketone using calcium plasma immersion ion implantation

被引：43

作者：

Lu, Tao ^{[1
]}

Qian, Shi ^{[1
]}

Meng, Fanhao ^{[1
]}

Ning, Congqin ^{[1
]}

Liu, Xuanyong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2016年 / 142卷

基金：

美国国家科学基金会;

关键词：

Plasma immersion ion implantation; PEEK; Calcium; Osteogenic activity; IN-VITRO; GENE-EXPRESSION; STROMAL CELLS; POLYETHERETHERKETONE; TITANIUM; SURFACE; BONE; BIOMATERIALS; PROLIFERATION;

D O I：

10.1016/j.colsurfb.2016.02.056

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

As a promising implantable material, poly ether ether ketone (PEEK) possesses similar elastic modulus to that of cortical bones yet suffers from bio-inertness and poor osteogenic properties, which limits its application as orthopedic implants. In this work, calcium is introduced onto PEEK surface using calcium plasma immersion ion implantation (Ca-PIII). The results obtained from scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) confirm the modified layer with varying contents of calcium are formed on PEEK surfaces. Water contact angle measurements reveal the increasing hydrophobicity of both Ca-PIII treated surfaces. In vitro cell adhesion, viability assay, alkaline phosphatase activity and collagen secretion analyses disclose improved the adhesion, proliferation, and osteo-differentiation of rat bone mesenchymal stem cells (bMSCs) on Ca-PIII treated surfaces. The obtained results indicate that PEEK surface with enhanced osteogenic activity can be produced by calcium incorporation. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：192 / 198

页数：7

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