Metal acetate/metal oxide in acetic acid: an efficient reagent for the chemoselective N-acetylation of amines under green conditions

被引：39

作者：

Brahmachari, Goutam ^{[1
]}

Laskar, Sujay ^{[1
]}

Sarkar, Sajal ^{[1
]}

机构：

[1] Visva Bharati Univ, Dept Chem, Lab Organ Synth & Nat Prod, Santini Ketan 731235, W Bengal, India

来源：

JOURNAL OF CHEMICAL RESEARCH | 2010年 / 05期

关键词：

amines; N-acetylation; chemoselectivity; metal acetates; metal oxides; acetic acid; SOLVENT-FREE CONDITIONS; HIGHLY EFFICIENT; CATALYZED ACETYLATION; ACYLATION REACTIONS; HETEROGENEOUS CATALYST; MICROWAVE IRRADIATION; FERRIC PERCHLORATE; VERSATILE REAGENT; ORGANIC-SYNTHESIS; SILICA-GEL;

D O I：

10.3184/030823410X12746305905926

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of catalytic amount of metal acetate or metal oxide in acetic acid is a new and highly efficient acetylating system for chemoselective N-acetylation of primary and secondary amines in excellent yields under reflux condition. No other solvent is required. The noted features of this method include mild reaction conditions, use of innocuous reagents, excellent yields, convenient work-up, and reuse of catalyst.

引用

页码：288 / 295

页数：8

共 72 条

[1] N-acetyl-N-acyl-3-aminoquinazolinones as chemoselective acetylating agents [J].