Expression analysis of NF-κB-associated long noncoding RNAs in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients

被引：8

作者：

Soltanmoradi, Samira ^{[1
]}

Tavakolpour, Vahid ^{[1
,2
]}

Moghadasi, Abdorreza Naser ^{[3
]}

Kouhkan, Fatemeh ^{[1
]}

机构：

[1] Stem Cell Technol Res Ctr, Tehran, Iran

[2] Natl Inst Genet Engn & Biotechnol, Fac Med Biotechnol, Dept Stem Cells & Regenerat Med, Tehran, Iran

[3] Univ Tehran Med Sci, Neurosci Inst, Multiple Sclerosis Res Ctr, Tehran, Iran

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 356卷

关键词：

Multiple sclerosis; HOTAIR; THRIL; H19; NKILA; ANRIL; GENE-EXPRESSION; TRANSCRIPTION FACTORS; GAMMA SECRETION; METASTASIS; ACTIVATION; CANCER; H19; PROTEIN; DEATH;

D O I：

10.1016/j.jneuroim.2021.577602

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Long noncoding RNAs (lncRNAs) as potential disease biomarkers might be related to severe course of multiple sclerosis (MS). We evaluated expression levels of NF-kappa B-associated lncRNAs including HOTAIR, THRIL, H19, NKILA, and ANRIL; as well as expression of IL-6, TNF-alpha and MMP9, in peripheral blood mononuclear cells (PBMCs) from 60 relapse-remitting MS (RRMS) patients. At relapse phase of RRMS, up-regulation of ANRIL and H19 was positively correlated with the overexpression of IL-6; high levels of THRIL and HOTAIR was positively correlated with increased levels of TNF-alpha and MMP9, respectively; however, the NKILA expression was negatively correlated with the expression of TNF-alpha.

引用

页数：10

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