Roles of NLRP3 inflammasome in intervertebral disc degeneration

被引：143

作者：

Chao-yang, G. ^{[1
,2
]}

Peng, C. ^{[1
,2
]}

Hai-hong, Z. ^{[1
]}

机构：

[1] Lanzhou Univ, Hosp 2, 82 Cuiying Men, Lanzhou 730000, Peoples R China

[2] Orthopaed Key Lab Gansu Prov, Lanzhou 730000, Peoples R China

来源：

OSTEOARTHRITIS AND CARTILAGE | 2021年 / 29卷 / 06期

关键词：

Intervertebral disc degeneration; NLRP3; Inflammasome; Intervertebral disc; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; CELL-DEATH; ACTIVATION; EXPRESSION; MECHANISM; IL-1-BETA; APOPTOSIS; CASPASE-8; PROTECTS;

D O I：

10.1016/j.joca.2021.02.204

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain and one of the most common health problems in the world. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome, as a pattern recognition receptor, has been shown to be associated with the pathological processes of many diseases in recent years. With the exploration of the mechanism of IVDD, recent studies have shown that activation of the NLRP3 inflammasome is associated with intervertebral disc (IVD) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of IVD cells. In this review, we summarize the structural characteristics of NLRP3 inflammasome and the activation signalling mechanisms. We also describe the role of the NLRP3 inflammasome in the pathological process of IVDD and the application of the targeting the NLRP3 inflammasome in IVDD treatment. (c) 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：793 / 801

页数：9

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