Roles of NLRP3 inflammasome in intervertebral disc degeneration

被引:143
作者
Chao-yang, G. [1 ,2 ]
Peng, C. [1 ,2 ]
Hai-hong, Z. [1 ]
机构
[1] Lanzhou Univ, Hosp 2, 82 Cuiying Men, Lanzhou 730000, Peoples R China
[2] Orthopaed Key Lab Gansu Prov, Lanzhou 730000, Peoples R China
关键词
Intervertebral disc degeneration; NLRP3; Inflammasome; Intervertebral disc; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; CELL-DEATH; ACTIVATION; EXPRESSION; MECHANISM; IL-1-BETA; APOPTOSIS; CASPASE-8; PROTECTS;
D O I
10.1016/j.joca.2021.02.204
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Intervertebral disc degeneration (IVDD) is one of the leading causes of low back pain and one of the most common health problems in the world. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome, as a pattern recognition receptor, has been shown to be associated with the pathological processes of many diseases in recent years. With the exploration of the mechanism of IVDD, recent studies have shown that activation of the NLRP3 inflammasome is associated with intervertebral disc (IVD) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of IVD cells. In this review, we summarize the structural characteristics of NLRP3 inflammasome and the activation signalling mechanisms. We also describe the role of the NLRP3 inflammasome in the pathological process of IVDD and the application of the targeting the NLRP3 inflammasome in IVDD treatment. (c) 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:793 / 801
页数:9
相关论文
共 74 条
[1]   Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome [J].
Afonina, Inna S. ;
Zhong, Zhenyu ;
Karin, Michael ;
Beyaert, Rudi .
NATURE IMMUNOLOGY, 2017, 18 (08) :861-869
[2]   Omnipresence of inflammasome activities in inflammatory bone diseases [J].
Alippe, Yael ;
Mbalaviele, Gabriel .
SEMINARS IN IMMUNOPATHOLOGY, 2019, 41 (05) :607-618
[3]   Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming [J].
Allam, Ramanjaneyulu ;
Lawlor, Kate E. ;
Yu, Eric Chi-Wang ;
Mildenhall, Alison L. ;
Moujalled, Donia M. ;
Lewis, Rowena S. ;
Ke, Francine ;
Mason, Kylie D. ;
White, Michael J. ;
Stacey, Katryn J. ;
Strasser, Andreas ;
O'Reilly, Lorraine A. ;
Alexander, Warren ;
Kile, Benjamin T. ;
Vaux, David L. ;
Vince, James E. .
EMBO REPORTS, 2014, 15 (09) :982-990
[4]   Epidemiological features of chronic low-back pain [J].
Andersson, GBJ .
LANCET, 1999, 354 (9178) :581-585
[5]   Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells [J].
Bai, Zhibiao ;
Liu, Wei ;
He, Danshuang ;
Wang, Yiyang ;
Yi, Weiwei ;
Luo, Changqi ;
Shen, Jieliang ;
Hu, Zhenming .
AGING-US, 2020, 12 (08) :7534-7548
[6]   Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3-and Caspase-2-Driven Mitochondrial Damage [J].
Bronner, Denise N. ;
Abuaita, Basel H. ;
Chen, Xiaoyun ;
Fitzgerald, Katherine A. ;
Nunez, Gabriel ;
He, Yongqun ;
Yin, Xiao-Ming ;
O'Riordan, Mary X. D. .
IMMUNITY, 2015, 43 (03) :451-462
[7]   Inflammasomes: mechanism of assembly, regulation and signalling [J].
Broz, Petr ;
Dixit, Vishva M. .
NATURE REVIEWS IMMUNOLOGY, 2016, 16 (07) :407-420
[8]   Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop [J].
Chen, Fan ;
Jiang, Guowei ;
Liu, Hui ;
Li, Zemin ;
Pei, Yuxin ;
Wang, Hua ;
Pan, Hehai ;
Cui, Haowen ;
Long, Jun ;
Wang, Jianru ;
Zheng, Zhaomin .
BONE RESEARCH, 2020, 8 (01)
[9]   Enhanced NLRP3, Caspase-1, and IL-1β Levels in Degenerate Human Intervertebral Disc and Their Association with the Grades of Disc Degeneration [J].
Chen, Zhong-Hua ;
Jin, Shen-Hui ;
Wang, Min-Yan ;
Jin, Xiao-Liang ;
Lv, Chen ;
Deng, Ying-Feng ;
Wang, Jun-Lu .
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2015, 298 (04) :720-726
[10]   Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation [J].
Cosin-Roger, Jesus ;
Simmen, Simona ;
Melhem, Hassan ;
Atrott, Kirstin ;
Frey-Wagner, Isabelle ;
Hausmann, Martin ;
de Valliere, Cheryl ;
Spalinger, Marianne R. ;
Spielmann, Patrick ;
Wenger, Roland H. ;
Zeitz, Jonas ;
Vavricka, Stephan R. ;
Rogler, Gerhard ;
Ruiz, Pedro A. .
NATURE COMMUNICATIONS, 2017, 8