The Self-Assembly of Anticancer Camptothecin-Dipeptide Nanotubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy

被引：73
作者：
Kim, Se Hye [1 ]
Kaplan, Jonah A. [2 ,3 ]
Sun, Yuan [1 ]
Shieh, Aileen [1 ]
Sun, Hui-Lung [4 ]
Croce, Carlo M. [4 ]
Grinstaff, Mark W. [2 ,3 ]
Parquette, Jon R. [1 ]
机构：
[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Boston Univ, Dept Chem, Boston, MA 02215 USA
[4] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 01期
基金：
美国国家科学基金会;
关键词：
anti-cancer prodrugs; high drug loading; nanomedicines; self-assembly; MAMMALIAN TOPOISOMERASE-I; PLGA-BASED NANOPARTICLES; HUMAN SERUM-ALBUMIN; ANTITUMOR-ACTIVITY; GOLD NANOPARTICLES; PHARMACOKINETIC TRIAL; IRINOTECAN CPT-11; CARBON NANOTUBES; DELIVERY-SYSTEM; CANCER-THERAPY;
D O I：
10.1002/chem.201404520
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
20-(S)-Camptothecin (CPT)-conjugated dipeptides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (similar to 47%) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro compared with the clinically used prodrug irinotecan. A key and defining feature of this system is the use of the CPT-conjugated dipeptide as both the drug and precursor to the nanostructured carrier, which simplifies the overall fabrication process.
引用
收藏
页码：101 / 105
页数：5
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共 73 条
  • [1] Dendrimeric micelles for controlled drug release and targeted delivery
    Ambade, Ashootosh V.
    Savariar, Elamprakash N.
    Thayumanavan, S.
    [J]. MOLECULAR PHARMACEUTICS, 2005, 2 (04) : 264 - 272
  • [2] Relevance of extracellular and intracellular interactions of camptothecins as determinants of antitumor activity
    Beretta, Giovanni Luca
    Zunino, Franco
    [J]. BIOCHEMICAL PHARMACOLOGY, 2007, 74 (10) : 1437 - 1444
  • [3] Liberation of drugs from multi-wall carbon nanotube carriers
    Boncel, Slawomir
    Zajac, Piotr
    Koziol, Krzysztof K. K.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2013, 169 (1-2) : 126 - 140
  • [4] Targetable HPMA Copolymer-Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy
    Borgman, Mark P.
    Ray, Abhijit
    Kolhatkar, Rohit B.
    Sausville, Edward A.
    Burger, Angelika M.
    Ghandehari, Hamidreza
    [J]. PHARMACEUTICAL RESEARCH, 2009, 26 (06) : 1407 - 1418
  • [5] THE STRUCTURAL BASIS OF CAMPTOTHECIN INTERACTIONS WITH HUMAN SERUM-ALBUMIN - IMPACT ON DRUG STABILITY
    BURKE, TG
    MI, ZH
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (01) : 40 - 46
  • [6] Antiangiogenic Targeting Liposomes Increase Therapeutic Efficacy for Solid Tumors
    Chang, De-Kuan
    Chiu, Chien-Yu
    Kuo, Szu-Yao
    Lin, Wei-Chuan
    Lo, Albert
    Wang, Yi-Ping
    Li, Pi-Chun
    Wu, Han-Chung
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (19) : 12905 - 12916
  • [7] Supramolecular Nanostructures Formed by Anticancer Drug Assembly
    Cheetham, Andrew G.
    Zhang, Pengcheng
    Lin, Yi-an
    Lock, Lye Lin
    Cui, Honggang
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (08) : 2907 - 2910
  • [8] Aggregation properties of a HPMA-camptothecin copolymer in isotonic solutions
    Chirico, G
    Collini, M
    Olivini, F
    Zamai, M
    Frigerio, E
    Caiolfa, VR
    [J]. BIOPHYSICAL CHEMISTRY, 2004, 110 (03) : 281 - 295
  • [9] Therapeutic nanoparticles for drug delivery in cancer
    Cho, Kwangjae
    Wang, Xu
    Nie, Shuming
    Chen, Zhuo
    Shin, Dong M.
    [J]. CLINICAL CANCER RESEARCH, 2008, 14 (05) : 1310 - 1316
  • [10] Biologically Responsive Polymeric Nanoparticles for Drug Delivery
    Colson, Yolonda L.
    Grinstaff, Mark W.
    [J]. ADVANCED MATERIALS, 2012, 24 (28) : 3878 - 3886
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