Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1

被引：50

作者：

Chang, Yiming ^{[1
]}

Schlenstedt, Gabriel

Flockerzi, Veit ^{[1
]}

Beck, Andreas ^{[1
]}

机构：

[1] Univ Saarland, Fak Med, Expt & Klin Pharmakol & Toxikol, D-66421 Homburg, Germany

来源：

FEBS LETTERS | 2010年 / 584卷 / 10期

关键词：

Yeast vacuolar conductance 1; Yeast cation channel; Tonoplast recording; Transient receptor potential channel; Calcium release; VACUOLAR MEMBRANE-VESICLES; PLANAR LIPID BILAYER; SACCHAROMYCES-CEREVISIAE; CATION CHANNEL; ION CHANNELS; RELEASE CHANNEL; CA2+; DROSOPHILA; CALCIUM; CELLS;

D O I：

10.1016/j.febslet.2009.12.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2028 / 2032

页数：5

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