COVID-19 and Sarcoidosis, Readiness for Vaccination: Challenges and Opportunities

被引:16
作者
Manansala, Michael [1 ]
Chopra, Amit [2 ]
Baughman, Robert P. [3 ]
Novak, Richard [4 ]
Lower, Elyse E. [3 ]
Culver, Daniel A. [5 ]
Korsten, Peter [6 ]
Drake, Wonder P. [7 ]
Judson, Marc A. [2 ]
Sweiss, Nadera [8 ]
机构
[1] Univ Illinois, Dept Med, Acad Internal Med, Chicago, IL USA
[2] Albany Med Coll, Div Pulm & Crit Care Med, Dept Med, Albany, NY 12208 USA
[3] Univ Cincinnati, Med Ctr, Dept Med, Cincinnati, OH 45267 USA
[4] Univ Illinois, Dept Med, Div Infect Dis, Chicago, IL USA
[5] Cleveland Clin, Dept Pulm Med, Cleveland, OH 44106 USA
[6] Univ Med Ctr Gottingen, Dept Nephrol & Rheumatol, Gottingen, Germany
[7] Vanderbilt Univ, Sch Med, Dept Med, Div Infect Dis, Nashville, TN 37212 USA
[8] Univ Illinois, Dept Med, Div Rheumatol, Chicago, IL 60607 USA
关键词
coronavirus; -COVID-19; sarcoidosis; vaccination; immunosuppression; SARS-CoV-2; INFLUENZA VACCINATION; RHEUMATOID-ARTHRITIS; IMMUNOGENICITY; STATES;
D O I
10.3389/fmed.2021.672028
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sarcoidosis is an immune mediated chronic inflammatory disorder that is best characterized by non-caseating granulomas found in one or more affected organs. The COVID-19 pandemic poses a challenge for clinicians caring for sarcoidosis patients who may be at increased risk of infection compared to the general population. With the recent availability of COVID-19 vaccines, it is expected that clinicians raise questions regarding efficacy and safety in sarcoidosis. However, studies examining safety and efficacy of vaccines in sarcoidosis are lacking. In this review, we examine the current literature regarding vaccination in immunocompromised populations and apply them to sarcoidosis patients. The available literature suggests that vaccines are safe and effective in patients with autoimmune disorders and in those taking immunosuppressive medications. We strongly recommend the administration of COVID-19 vaccines in patients with sarcoidosis. We also present a clinical decision algorithm to provide guidance on vaccination of sarcoidosis patients against COVID-19.
引用
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页数:7
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