Human Y chromosome, sex determination, and spermatogenesis - A feminist view

被引：49

作者：

Graves, JAM ^{[1
]}

机构：

[1] La Trobe Univ, Dept Genet, Melbourne, Vic 3093, Australia

来源：

BIOLOGY OF REPRODUCTION | 2000年 / 63卷 / 03期

关键词：

Sertoli cells; spermatogenesis;

D O I：

10.1095/biolreprod63.3.667b

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this review I want to argue that, far from being a macho entity with an all-powerful role in male development, the human Y chromosome is a "wimp." It is merely a relic of the X chromosome, and most or all of the genes it bears-including the genes that determine sex and control spermatogenesis-are relies of genes on the X chromosome that have other functions altogether.

引用

页码：667 / 676

页数：10

共 44 条

[1] Sry requires a CAG repeat domain for male sex determination in Mus musculus [J].

Bowles, J ;

Cooper, L ;

Berkman, J ;

Koopman, P .

NATURE GENETICS, 1999, 22 (04) :405-408

[2] Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and manning to the Sxrb interval of the mouse Y chromosome of the Dffry gene [J].

Brown, GM ;

Furlong, RA ;

Sargent, CA ;

Erickson, RP ;

Longepied, G ;

Mitchell, M ;

Jones, MH ;

Hargreave, TB ;

Cooke, HJ ;

Affara, NA .

HUMAN MOLECULAR GENETICS, 1998, 7 (01) :97-107

[3]

BURGOYNE P, 1992, ADV DEV BIOL, V1, P1

[4] THE EVOLUTION OF SEX-CHROMOSOMES [J].

CHARLESWORTH, B .

SCIENCE, 1991, 251 (4997) :1030-1033

[5]

Collignon J, 1996, DEVELOPMENT, V122, P509

[6]

Cooper D.W., 1993, Seminars in Developmental Biology, V4, P117, DOI 10.1006/sedb.1993.1014

[7] A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome [J].

Delbridge, ML ;

Harry, JL ;

Toder, R ;

ONeill, RJW ;

Ma, K ;

Chandley, AC ;

Graves, JAM .

NATURE GENETICS, 1997, 15 (02) :131-136

[8] The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome [J].

Delbridge, ML ;

Lingenfelter, PA ;

Disteche, CM ;

Graves, JAM .

NATURE GENETICS, 1999, 22 (03) :223-224

[9]

FORD CE, 1959, LANCET, V1, P711

[10] CAMPOMELIC DYSPLASIA AND AUTOSOMAL SEX REVERSAL CAUSED BY MUTATIONS IN AN SRY-RELATED GENE [J].

FOSTER, JW ;

DOMINGUEZSTEGLICH, MA ;

GUIOLI, S ;

KWOK, C ;

WELLER, PA ;

STEVANOVIC, M ;

WEISSENBACH, J ;

MANSOUR, S ;

YOUNG, ID ;

GOODFELLOW, PN ;

BROOK, JD ;

SCHAFER, AJ .

NATURE, 1994, 372 (6506) :525-530

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