5-azidoepibatidine:: An exceptionally potent photoaffinity ligand for neuronal α4β2 and α7 nicotinic acetylcholine receptors

被引：20

作者：

Zhang, NJ ^{[1
]}

Tomizawa, M ^{[1
]}

Casida, JE ^{[1
]}

机构：

[1] Univ Calif Berkeley, Environm Chem & Toxicol Lab, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)00936-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Racemic 5-azidoepibatidine [(+/-)-1] was synthesized via 5-aminoepibatidine as a candidate photoaffinity ligand with exceptionally high affinity at the mammalian neuronal nicotinic receptors (K-i values of 0.027 nM for alpha4beta2 and 9.7 nM for alpha7) and excellent photoreactivity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：525 / 527

页数：3

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