Chitosan-PVA-co-poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Hybrid IPN-Nanogels for Transdermal Delivery of Ondansetron; Synthesis, Characterization and Toxicological Evaluation

被引：19

作者：

Tanveer, Sana ^{[1
]}

Ahmad, Mahmood ^{[1
]}

Minhas, Muhammad Usman ^{[2
]}

Ahmad, Aousaf ^{[1
]}

Khan, Kifayat Ullah ^{[1
]}

机构：

[1] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Khawaja Fareed Campus, Bahawalpur, Punjab, Pakistan

[2] Univ Sargodha, Coll Pharm, Sargodha, Punjab, Pakistan

来源：

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | 2021年 / 60卷 / 17期

关键词：

Nanogels; ondansetron; chitosan; poly vinyl alcohol; transdermal delivery; CHEMOTHERAPY-INDUCED NAUSEA; VITRO DRUG-RELEASE; IN-VITRO; POLYVINYL-ALCOHOL; RHEOLOGICAL PROPERTIES; ALGINATE HYDROGEL; CARBOPOL GEL; SEMI-IPN; HYDROCHLORIDE; NETWORK;

D O I：

10.1080/25740881.2021.1934019

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Current study aimed to develop and evaluate interpenetrating polymer network (IPN) nanogels for transdermal delivery of ondansetron (OND) using combination of natural and synthetic polymers. Owing to their small size and biocompatible profile, nanogels have great potential as carriers for transdermal delivery that aids in penetration of drugs through layers of skin into blood stream. IPN nanogels were synthesized by free radical polymerization technique. Effective response for swelling and drug release were quantified at pH 5.5 and 7.4 simulating skin and blood. Overall results were satisfactory concluding that prepared IPN-nanogels were stable with excellent drug permeation profile across skin.

引用

页码：1913 / 1934

页数：22

共 99 条

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