Synaptotagmins: That's Why So Many

被引：20

作者：

Chen, Chong ^{[1
]}

Jonas, Peter ^{[1
]}

机构：

[1] IST Austria, Campus 1, A-3400 Klosterneuburg, Austria

来源：

NEURON | 2017年 / 94卷 / 04期

基金：

奥地利科学基金会;

关键词：

TRANSMITTER RELEASE; SENSORS;

D O I：

10.1016/j.neuron.2017.05.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Sudhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains, resulting in reliable and temporally precise high-frequency transmission. Thus, a slow Ca2+ sensor contributes to the fast signaling properties of the calyx synapse.

引用

页码：694 / 696

页数：3

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