Cyclooxygenase-2 expression in canine mammary tumors

被引：93

作者：

Doré, M ^{[1
]}

Lanthier, I ^{[1
]}

Sirois, J ^{[1
]}

机构：

[1] Univ Montreal, Fac Med Vet, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 7C6, Canada

来源：

VETERINARY PATHOLOGY | 2003年 / 40卷 / 02期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

cyclooxygenase-2; dogs; mammary tumors; prostaglandins;

D O I：

10.1354/vp.40-2-207

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mammary tumors are the most common neoplasms in female dogs. Induction of cyclooxygenase-2 (COX-2) has been implicated in various cancers in humans. However, expression of COX-2 has not been investigated in canine mammary tumors. Normal mammary gland (n = 4), simple or complex adenomas (n = 63), and simple or complex adenocarcinomas (n = 84) were studied by immunohistochemistry. Results showed that COX-2 was not expressed in the normal gland but was detected in 24% of adenomas and in 56% of adenocarcinomas (P < 0.001). The incidence of COX-2 expression and the intensity of the COX-2 signal were higher in adenocarcinomas than in adenomas (P < 0.001). These results demonstrate for the first time that COX-2 is induced in a proportion of canine mammary tumors and that COX-2 expression is more frequent and more intense in malignant than in benign tumors, suggesting a potential role for COX-2 in canine mammary tumorigenesis.

引用

页码：207 / 212

页数：6

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