Cyclooxygenase-2 expression in canine mammary tumors

被引:93
作者
Doré, M [1 ]
Lanthier, I [1 ]
Sirois, J [1 ]
机构
[1] Univ Montreal, Fac Med Vet, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 7C6, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
cyclooxygenase-2; dogs; mammary tumors; prostaglandins;
D O I
10.1354/vp.40-2-207
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Mammary tumors are the most common neoplasms in female dogs. Induction of cyclooxygenase-2 (COX-2) has been implicated in various cancers in humans. However, expression of COX-2 has not been investigated in canine mammary tumors. Normal mammary gland (n = 4), simple or complex adenomas (n = 63), and simple or complex adenocarcinomas (n = 84) were studied by immunohistochemistry. Results showed that COX-2 was not expressed in the normal gland but was detected in 24% of adenomas and in 56% of adenocarcinomas (P < 0.001). The incidence of COX-2 expression and the intensity of the COX-2 signal were higher in adenocarcinomas than in adenomas (P < 0.001). These results demonstrate for the first time that COX-2 is induced in a proportion of canine mammary tumors and that COX-2 expression is more frequent and more intense in malignant than in benign tumors, suggesting a potential role for COX-2 in canine mammary tumorigenesis.
引用
收藏
页码:207 / 212
页数:6
相关论文
共 28 条
[1]  
COHEN D, 1974, CANCER RES, V34, P2859
[2]   Expression of cyclo-oxygenase-2 in naturally occurring squamous cell carcinomas in dogs [J].
de Almeida, EMP ;
Piché, C ;
Sirois, J ;
Doré, M .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2001, 49 (07) :867-875
[3]  
DeWitt DL, 1999, MOL PHARMACOL, V55, P625
[4]   CANINE MAMMARY EPITHELIAL NEOPLASMS - BIOLOGIC IMPLICATIONS OF MORPHOLOGIC CHARACTERISTICS ASSESSED IN 232 DOGS [J].
GILBERTSON, SR ;
KURZMAN, ID ;
ZACHRAU, RE ;
HURVITZ, AI ;
BLACK, MM .
VETERINARY PATHOLOGY, 1983, 20 (02) :127-142
[5]  
Half E, 2002, CANCER RES, V62, P1676
[6]  
Harris RE, 2000, CANCER RES, V60, P2101
[7]   Cyclooxygenase-5: a target for the prevention and treatment of breast cancer [J].
Howe, LR ;
Subbaramaiah, K ;
Brown, AMC ;
Dannenberg, AJ .
ENDOCRINE-RELATED CANCER, 2001, 8 (02) :97-114
[8]   Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer [J].
Hwang, D ;
Scollard, D ;
Byrne, J ;
Levine, E .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (06) :455-460
[9]   Expression of cyclooxygenase-2 in canine renal cell carcinoma [J].
Khan, KNM ;
Stanfield, KM ;
Trajkovic, D ;
Knapp, DW .
VETERINARY PATHOLOGY, 2001, 38 (01) :116-119
[10]   PHASE-I TRIAL OF PIROXICAM IN 62 DOGS BEARING NATURALLY-OCCURRING TUMORS [J].
KNAPP, DW ;
RICHARDSON, RC ;
BOTTOMS, GD ;
TECLAW, R ;
CHAN, TCK .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1992, 29 (03) :214-218