Population-level Mortality Associated with HIV Exposure in HIV-uninfected Infants in Botswana and South Africa: A Model-based Evaluation

被引：11

作者：

Slogrove, Amy L. ^{[1
,2
]}

Johnson, Leigh F. ^{[3
]}

Powis, Kathleen M. ^{[4
,5
,6
]}

机构：

[1] Stellenbosch Univ, Dept Paediat & Child Hlth, Fac Med & Hlth Sci, Worcester, South Africa

[2] Stellenbosch Univ, Fac Med & Hlth Sci, Ukwanda Ctr Rural Hlth, Worcester, South Africa

[3] Univ Cape Town, Sch Publ Hlth & Family Med, Ctr Infect Dis Epidemiol & Res, Fac Hlth Sci, Cape Town, South Africa

[4] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA

[5] Massachusetts Gen Hosp, Dept Internal Med & Pediat, Boston, MA 02114 USA

[6] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2019年 / 65卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV-exposed uninfected; HEU; infant mortality; South Africa; Botswana; MOTHER-TO-CHILD; SYSTEMATIC ANALYSIS; GLOBAL BURDEN; RISK-FACTORS; HEALTH; TRANSMISSION; PROGRAM; DISEASE;

D O I：

10.1093/tropej/fmy064

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We aimed to quantify the contribution of excess mortality in HIV-exposed uninfected (HEU) infants to total mortality in HIV-uninfected infants in Botswana and South Africa in 2013. Population attributable fractions (PAFs) and excess infant deaths associated with HIV exposure in HIV-uninfected infants were estimated. Additionally, the Thembisa South African demographic model estimated the proportion of all infant mortality associated with excess mortality in HEU infants from 1990 to 2013. The PAF (lower bound; upper bound) of mortality associated with HIV exposure in HIV-uninfected infants was 16.8% (2.5; 31.2) in Botswana and 15.1% (2.2; 28.2) in South Africa. Excess infant deaths (lower bound; upper bound) associated with HIV exposure in 2013 were estimated to be 5.6 (0.5; 16.6)/1000 and 4.9 (0.6; 11.2)/1000 HIV-uninfected infants in Botswana and South Africa, respectively. In South Africa, the proportion of all infant (HIV-infected and HIV-uninfected) mortality associated with excess HEU infant mortality increased from 0.4% in 1990 to 13.8% in 2013.

引用

页码：373 / 379

页数：7

共 32 条

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Zash, Rebecca ;

Souda, Sajini ;

Leidner, Jean ;

Ribaudo, Heather ;

Binda, Kelebogile ;

Moyo, Sikhulile ;

Powis, Kathleen M. ;

Petlo, Chipo ;

Mmalane, Mompati ;

Makhema, Joe ;

Essex, Max ;

Lockman, Shahin ;

Shapiro, Roger .

BMC PEDIATRICS, 2016, 16

[32]

2013, CONGUID UANT DRU, P1, DOI DOI 10.1596/978-0-8213-9545-5

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