C-H Activation/Metalation Approaches for the Synthesis of Indolizine Derivatives

被引：18

作者：

Bertallo, Camila R. de S. ^{[1
]}

Arroio, Thais R. ^{[1
]}

Toledo, Monica F. Z. J. ^{[1
]}

Sadler, Scott A. ^{[2
]}

Vessecchi, Ricardo ^{[3
]}

Steel, Patrick G. ^{[2
]}

Clososki, Giuliano C. ^{[1
,3
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisas Prod Nat & Sintet, Av Cafe S-N, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Durham, Dept Chem, South Rd, Durham DH1 3LE, England

[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP, Brazil

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 31-32期

基金：

英国工程与自然科学研究理事会; 巴西圣保罗研究基金会;

关键词：

C-H borylation; Metalation; Indolizines; Cross-coupling; Heterocycles; ONE-POT; IRIDIUM COMPLEXES; BORYLATION; FUNCTIONALIZATION; FLUORESCENT; METALATION; AROMATICS; ZINCATION; MAGNESIUM; ARENES;

D O I：

10.1002/ejoc.201900608

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-H borylation of indolizines has not previously been reported. In this communication, we describe our preliminary efforts to apply this chemistry to this scaffold and contrast this approach to directed metalation. Through these methodologies, it was possible obtain a library of substituted indolizines functionalized on both the pyridinic and pyrrole rings.

引用

页码：5205 / 5213

页数：9

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