Studies on the interaction between rutin and DNA in the absence and presence of β-cyclodextrin by electrochemical and spectroscopic methods

被引：0
作者：
Yang, GJ [1 ]
Xu, JJ
Chen, HY
Leng, ZZ
机构：
[1] Nanjing Univ, Dept Chem, State Key Lab Coordinat Chem, Inst Analyt Sci, Nanjing 210093, Peoples R China
[2] Yangzhou Univ, Coll Chem & Engn, Yangzhou 225002, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2004年 / 22卷 / 11期
关键词：
rutin; DNA; beta-cyclodextrin; cyclic voltammetry; UV-vis absorption spectroscopy; fluorescence emission spectroscopy; interaction;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions between rutin or the inclusion complex of rutin-beta-cyclodextrin and DNA were investigated by means of cyclic voltammetry, UV-vis absorption spectroscopy and fluorescence emission spectroscopy. The apparent binding constant of rutin with DNA is found to be 2.9 x 10(4) L/mol. The results showed that the benzopyranic-4-one plane of rutin mainly intercalated into DNA in the absence of beta-cyclodextrin, while the catecholic portion of rutin was located in the double helix of DNA in the presence of beta-cyclodextrin.
引用
收藏
页码：1325 / 1329
页数：5
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