Scope: Aflatoxin exposure coincides with micronutrient deficiencies in developing countries. Animal feeding studies have postulated that aflatoxin exposure may be exacerbating micronutrient deficiencies. Evidence available in human subjects is limited and inconsistent. The aim of the study was to investigate the relationship between aflatoxin exposure and micronutrient status among young Guinean children. Methods and results: A total of 305 children (28.8 +/- 8.4 months) were recruited at groundnut harvest (rainy season), of which 288 were followed up 6 months later postharvest (dry season). Blood samples were collected at each visit. Aflatoxin-albumin adduct levels were measured by ELISA. Vitamin A, vitamin E and beta-carotene concentrations were measured using HPLC methods. Zinc was measured by atomic absorption spectroscopy. Aflatoxin exposure and micronutrient deficiencies were prevalent in this population and were influenced by season, with levels increasing between harvest and postharvest. At harvest, children in the highest aflatoxin exposure group, compared to the lowest, were 1.98 (95% CI: 1.00, 3.92) and 3.56 (95% CI: 1.13, 11.15) times more likely to be zinc and vitamin A deficient. Conclusion: Although children with high aflatoxin exposure levels were more likely to be zinc and vitamin A deficient, further research is necessary to determine a cause and effect relationship.
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Turner, Paul C.
Collinson, Andrew C.
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机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Collinson, Andrew C.
Cheung, Yin Bun
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机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Cheung, Yin Bun
Gong, YunYun
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机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Gong, YunYun
Hall, Andrew J.
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机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Hall, Andrew J.
Prentice, Andrew M.
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机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Prentice, Andrew M.
Wild, Christopher P.
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Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, EnglandUniv Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Turner, Paul C.
Collinson, Andrew C.
论文数: 0引用数: 0
h-index: 0
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Collinson, Andrew C.
Cheung, Yin Bun
论文数: 0引用数: 0
h-index: 0
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Cheung, Yin Bun
Gong, YunYun
论文数: 0引用数: 0
h-index: 0
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Gong, YunYun
Hall, Andrew J.
论文数: 0引用数: 0
h-index: 0
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Hall, Andrew J.
Prentice, Andrew M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England
Prentice, Andrew M.
Wild, Christopher P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, EnglandUniv Leeds, Fac Med & Hlth, Leeds Inst Genet Hlth & Therapeut, Ctr Biostat & Epidemiol,Mol Epidemiol Unit, Leeds, W Yorkshire, England