Dietary exposure to aflatoxin and micronutrient status among young children from Guinea

被引:19
作者
Watson, Sinead [1 ]
Chen, Gaoyun [1 ]
Sylla, Abdoulaye [2 ]
Routledge, Michael N. [3 ]
Gong, Yun Yun [1 ,3 ]
机构
[1] Queens Univ Belfast, Sch Biol Sci, Inst Global Food Secur, Belfast, Antrim, North Ireland
[2] Inst Pasteur Guinee, Kindia, Guinea
[3] Univ Leeds, Sch Med, Div Epidemiol, Leeds LS2 9JT, W Yorkshire, England
基金
英国惠康基金;
关键词
Aflatoxin; Biomarker; Children; Micronutrient deficiency; Seasonal variations; ALBUMIN ADDUCTS; PLASMA-CONCENTRATIONS; IMPAIRED GROWTH; BROILER CHICKS; WEST-AFRICA; VITAMIN-E; HEALTH; BENIN; DETERMINANTS; INFECTION;
D O I
10.1002/mnfr.201500382
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Scope: Aflatoxin exposure coincides with micronutrient deficiencies in developing countries. Animal feeding studies have postulated that aflatoxin exposure may be exacerbating micronutrient deficiencies. Evidence available in human subjects is limited and inconsistent. The aim of the study was to investigate the relationship between aflatoxin exposure and micronutrient status among young Guinean children. Methods and results: A total of 305 children (28.8 +/- 8.4 months) were recruited at groundnut harvest (rainy season), of which 288 were followed up 6 months later postharvest (dry season). Blood samples were collected at each visit. Aflatoxin-albumin adduct levels were measured by ELISA. Vitamin A, vitamin E and beta-carotene concentrations were measured using HPLC methods. Zinc was measured by atomic absorption spectroscopy. Aflatoxin exposure and micronutrient deficiencies were prevalent in this population and were influenced by season, with levels increasing between harvest and postharvest. At harvest, children in the highest aflatoxin exposure group, compared to the lowest, were 1.98 (95% CI: 1.00, 3.92) and 3.56 (95% CI: 1.13, 11.15) times more likely to be zinc and vitamin A deficient. Conclusion: Although children with high aflatoxin exposure levels were more likely to be zinc and vitamin A deficient, further research is necessary to determine a cause and effect relationship.
引用
收藏
页码:511 / 518
页数:8
相关论文
共 45 条
  • [31] THURNHAM DI, 1988, CLIN CHEM, V34, P377
  • [32] Aflatoxin exposure in utero causes growth faltering in Gambian infants
    Turner, Paul C.
    Collinson, Andrew C.
    Cheung, Yin Bun
    Gong, YunYun
    Hall, Andrew J.
    Prentice, Andrew M.
    Wild, Christopher P.
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2007, 36 (05) : 1119 - 1125
  • [33] Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study
    Turner, PC
    Sylla, A
    Gong, YY
    Diailo, MS
    Sutcliffe, AE
    Hall, AJ
    Wild, CP
    [J]. LANCET, 2005, 365 (9475) : 1950 - 1956
  • [34] Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure
    Turner, PC
    Sylla, A
    Kuang, SY
    Marchant, CL
    Diallo, MS
    Hall, AJ
    Groopman, JD
    Wild, CP
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (08) : 2053 - 2055
  • [35] The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: A basis for primary prevention in Guinea-Conakry, West Africa
    Turner, PC
    Sylla, A
    Diallo, MS
    Castegnaro, JJ
    Hall, AJ
    Wild, CP
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2002, 17 : S441 - S448
  • [36] Modification of immune function through exposure to dietary aflatoxin in Gambian children
    Turner, PC
    Moore, SE
    Hall, AJ
    Prentice, AM
    Wild, CP
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2003, 111 (02) : 217 - 220
  • [37] Hepatitis B infection and aflatoxin biomarker levels in Gambian children
    Turner, PC
    Mendy, M
    Whittle, H
    Fortuin, M
    Hall, AJ
    Wild, CP
    [J]. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2000, 5 (12) : 837 - 841
  • [38] Seasonal Hunger: A Neglected Problem with Proven Solutions
    Vaitla, Bapu
    Devereux, Stephen
    Swan, Samuel Hauenstein
    [J]. PLOS MEDICINE, 2009, 6 (06):
  • [39] Estimating the Global Prevalence of Zinc Deficiency: Results Based on Zinc Availability in National Food Supplies and the Prevalence of Stunting
    Wessells, K. Ryan
    Brown, Kenneth H.
    [J]. PLOS ONE, 2012, 7 (11):
  • [40] Mycotoxins and human disease: a largely ignored global health issue
    Wild, Christopher P.
    Gong, Yun Yun
    [J]. CARCINOGENESIS, 2010, 31 (01) : 71 - 82