Synthesis via α-halo vinyl ethers.: 5.: Heck reaction with an acyl synthon:: new coupling reaction between α-halo vinyl ether and alkene

被引：4

作者：

Gao, XB ^{[1
]}

Yu, WS ^{[1
]}

Mei, Y ^{[1
]}

Jin, ZD ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 44期

关键词：

alpha-halo vinyl ether; Heck reaction; vinyl ether; masked ketone;

D O I：

10.1016/j.tetlet.2004.09.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Halo vinyl ethers were successfully applied to palladium-catalyzed Heck reaction. Reactions of alpha-halo vinyl ether with alkenes under various Heck conditions form a new carbon-carbon bond along with a vinyl ether functionality, which can be further manipulated. This is the first synthetic methodology for the coupling of an acyl synthon with alkene employing Heck reaction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8169 / 8171

页数：3

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