Response to the Combination of Osimertinib and Trametinib in a Patient With EGFR-Mutant NSCLC Harboring an Acquired BRAF Fusion

被引：33

作者：

Dagogo-Jack, Ibiayi ^{[1
]}

Piotrowska, Zofia ^{[1
]}

Cobb, Rosemary ^{[1
]}

Banwait, Mandeep ^{[1
]}

Lennerz, Jochen K. ^{[2
]}

Hata, Aaron N. ^{[1
]}

Digumarthy, Subba R. ^{[1
]}

Sequist, Lecia V. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

来源：

JOURNAL OF THORACIC ONCOLOGY | 2019年 / 14卷 / 10期

关键词：

D O I：

10.1016/j.jtho.2019.05.046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：E226 / E228

页数：4

共 10 条

[1] BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma [J].

Kulkarni, Atul ;

Al-Hraishawi, Husam ;

Simhadri, Srilatha ;

Hirshfield, Kim M. ;

Chen, Suzie ;

Pine, Sharon ;

Jeyamohan, Chandrika ;

Sokol, Levi ;

Ali, Siraj ;

Teo, Man Lung ;

White, Eileen ;

Rodriguez-Rodriguez, Lorna ;

Mehnert, Janice M. ;

Ganesan, Shridar .

CLINICAL CANCER RESEARCH, 2017, 23 (18) :5631-5638

[2] Acquired ALK and RET Gene Fusions as Mechanisms of Resistance to Osimertinib in EGFR-Mutant Lung Cancers [J].

Offin, Michael ;

Somwar, Romel ;

Rekhtman, Natasha ;

Benayed, Ryma ;

Chang, Jason C. ;

Plodkowski, Andrew ;

Lui, Allan J. W. ;

Eng, Juliana ;

Rosenblum, Marc ;

Li, Bob T. ;

Riely, Gregory J. ;

Rudin, Charles M. ;

Kris, Mark G. ;

Travis, William ;

Drilon, Alexander ;

Arcila, Maria E. ;

Ladanyi, Marc ;

Yu, Helena A. .

JCO PRECISION ONCOLOGY, 2018, 2 :1-12

[3] Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T79OM-Positive Lung Cancer and Acquired Resistance to Osimertinib [J].

Oxnard, Geoffrey R. ;

Hu, Yuebi ;

Mileham, Kathryn F. ;

Husain, Hatim ;

Costa, Daniel B. ;

Tracy, Philip ;

Feeney, Nora ;

Sholl, Lynette M. ;

Dahlberg, Suzanne E. ;

Redig, Amanda J. ;

Kwiatkowski, David J. ;

Rabin, Michael S. ;

Paweletz, Cloud P. ;

Thress, Kenneth S. ;

Janne, Pasi A. .

JAMA ONCOLOGY, 2018, 4 (11) :1527-1534

[4] Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion [J].

Piotrowska, Zofia ;

Isozaki, Hideko ;

Lennerz, Jochen K. ;

Gainor, Justin F. ;

Lennes, Inga T. ;

Zhu, Viola W. ;

Marcoux, Nicolas ;

Banwait, Mandeep K. ;

Digumarthy, Subba R. ;

Su, Wenjia ;

Yoda, Satoshi ;

Riley, Amanda K. ;

Nangia, Varuna ;

Lin, Jessica J. ;

Nagy, Rebecca J. ;

Lanman, Richard B. ;

Dias-Santagata, Dora ;

Mino-Kenudson, Mari ;

Iafrate, A. John ;

Heist, Rebecca S. ;

Shaw, Alice T. ;

Evans, Erica K. ;

Clifford, Corinne ;

Ou, Sai-Hong, I ;

Wolf, Beni ;

Hata, Aaron N. ;

Sequist, Lecia, V .

CANCER DISCOVERY, 2018, 8 (12) :1529-1539

[5] Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors [J].

Schrock, Alexa B. ;

Zhu, Viola W. ;

Hsieh, Wen-Son ;

Madison, Russell ;

Creelan, Benjamin ;

Silberberg, Jeffrey ;

Costin, Dan ;

Bharne, Anjali ;

Bonta, Ioana ;

Bosemani, Thangavijayan ;

Nikolinakos, Petros ;

Ross, Jeffrey S. ;

Miller, Vincent A. ;

Ali, Siraj M. ;

Klempner, Samuel J. ;

Ou, Sai-Hong Ignatius .

JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (09) :1312-1323

[6]

Sequist LV, ABSTRACT CT0033 TATT

[7] Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer [J].

Soria, J. -C. ;

Ohe, Y. ;

Vansteenkiste, J. ;

Reungwetwattana, T. ;

Chewaskulyong, B. ;

Lee, K. H. ;

Dechaphunkul, A. ;

Imamura, F. ;

Nogami, N. ;

Kurata, T. ;

Okamoto, I. ;

Zhou, C. ;

Cho, B. C. ;

Cheng, Y. ;

Cho, E. K. ;

Voon, P. J. ;

Planchard, D. ;

Su, W. -C. ;

Gray, J. E. ;

Lee, S. -M. ;

Hodge, R. ;

Marotti, M. ;

Rukazenkov, Y. ;

Ramalingam, S. S. ;

Boyer, Michael ;

Lee, Chee ;

Hughes, Brett ;

O'Byrne, Kenneth ;

Briggs, Peter ;

Milward, Michael ;

John, Thomas ;

Demedts, Ingel ;

Vansteenkiste, Johan ;

Bustin, Frederique ;

Barrios, Carlos Henrique ;

Timcheva, Constanta ;

Butts, Charles ;

Goss, Glenwood ;

Juergens, Rosalyn ;

Leighl, Natasha ;

Cheng, Susanna ;

Burkes, Ronald ;

Zhou, Caicun ;

Zhang, Helong ;

Shu, Yongqian ;

Cheng, Ying ;

Zhou, Qing ;

Li, Wei ;

Feng, Guosheng ;

He, Yong .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (02) :113-125

[8] Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers [J].

Vojnic, Morana ;

Kubota, Daisuke ;

Kurzatkowski, Christopher ;

Offin, Michael ;

Suzawa, Ken ;

Benayed, Ryma ;

Schoenfeld, Adam J. ;

Plodkowski, Andrew J. ;

Poirier, John T. ;

Rudin, Charles M. ;

Kris, Mark G. ;

Rosen, Neal X. ;

Yu, Helena A. ;

Riely, Gregory J. ;

Arcila, Maria E. ;

Somwar, Romel ;

Ladanyi, Marc .

JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (05) :802-815

[9] RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling [J].

Yao, Zhan ;

Gao, Yijun ;

Su, Wenjing ;

Yaeger, Rona ;

Tao, Jessica ;

Na, Na ;

Zhang, Ying ;

Zhang, Chao ;

Rymar, Andrey ;

Tao, Anthony ;

Timaul, Neilawattie M. ;

Mcgriskin, Rory ;

Outmezguine, Nathaniel A. ;

Zhao, HuiYong ;

Chang, Qing ;

Qeriqi, Besnik ;

Barbacid, Mariano ;

de Stanchina, Elisa ;

Hyman, David M. ;

Bollag, Gideon ;

Rosen, Neal .

NATURE MEDICINE, 2019, 25 (02) :284-+

[10] Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS [J].

Yao, Zhan ;

Yaeger, Rona ;

Rodrik-Outmezguine, Vanessa S. ;

Tao, Anthony ;

Torres, Neilawattie M. ;

Chang, Matthew T. ;

Drosten, Matthias ;

Zhao, Huiyong ;

Cecchi, Fabiola ;

Hembrough, Todd ;

Michels, Judith ;

Baumert, Herve ;

Miles, Linde ;

Campbell, Naomi M. ;

de Stanchina, Elisa ;

Solit, David B. ;

Barbacid, Mariano ;

Taylor, Barry S. ;

Rosen, Neal .

NATURE, 2017, 548 (7666) :234-+

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