Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder

被引:19
作者
Tsai, SJ
Hong, CJ
Yu, YWY
Chen, TJ
Wang, YC
Lin, WK
机构
[1] Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Div Psychiat, Taipei 112, Taiwan
[3] E DA Hosp, Dept Psychiat, Kaohsiung, Taiwan
[4] I Shou Univ, Kaohsiung, Taiwan
[5] Kai Suan Psychiat Hosp, Kaohsiung, Taiwan
[6] Yu Li Vet Hosp, Sect Psychiat, Hualien, Taiwan
关键词
serotonin 1B receptor; major depressive disorder; polymorphism; selective serotonin reuptake inhibitors; suicide; treatment response;
D O I
10.1159/000079977
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Serotonin 1B receptors (5-HT1B) are autoreceptors involved in the local inhibitory control of serotonin release, and have been suggested to play a role in the pathogenesis of major depressive disorder (MDD) and the antidepressant effects of the selective serotonin reuptake inhibitors in patients. We genotyped the 5-HT1BA-161T polymorphism in 160 patients with MDD and 160 normal controls. We then tested the hypothesis that the allelic variant, A-161T, of the 5-HT1B gene confers susceptibility to MDD or is associated with suicide attempt. We also examined the association of this polymorphism with therapeutic response in 116 of the MDD patients who received fluoxetine treatment for 4 weeks. No significant difference was found in the A-161T genetic polymorphism between MDD patients and controls. The genotype distribution between patients with and without suicide attempt, or between fluoxetine treatment responders and nonresponders were also similar. Our findings suggest that 5-HT1BA-161T genetic polymorphism does not play a major role in the susceptibility to MDD, nor is it related to suicidal attempt or the therapeutic response to fluoxetine in MDD. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:235 / 238
页数:4
相关论文
共 24 条
[1]  
BLIER P, 1990, J CLIN PSYCHIAT, V51, P14
[2]   Involvement of serotonin and dopamine in the mechanism of action of novel antidepressant drugs: A review [J].
Bonhomme, N ;
Esposito, E .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1998, 18 (06) :447-454
[3]   NEUROBIOLOGICAL MECHANISMS INVOLVED IN ANTIDEPRESSANT THERAPIES [J].
BRILEY, M ;
MORET, C .
CLINICAL NEUROPHARMACOLOGY, 1993, 16 (05) :387-400
[4]   Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice [J].
Brunner, D ;
Hen, R .
NEUROBIOLOGY OF SUICIDE: FROM THE BENCH TO THE CLINIC, 1997, 836 :81-105
[5]   The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy [J].
Fehr, C ;
Grintschuk, N ;
Szegedi, A ;
Anghelescu, I ;
Klawe, C ;
Singer, P ;
Hiemke, C ;
Dahmen, N .
PSYCHIATRY RESEARCH, 2000, 97 (01) :1-10
[6]   MOLECULAR-CLONING AND FUNCTIONAL-CHARACTERIZATION OF A HUMAN 5-HT1B SEROTONIN RECEPTOR - A HOMOLOG OF THE RAT 5-HT1B RECEPTOR WITH 5-HT1D-LIKE PHARMACOLOGICAL SPECIFICITY [J].
HAMBLIN, MW ;
METCALF, MA ;
MCGUFFIN, RW ;
KARPELLS, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (02) :752-759
[7]  
HAMILTON M, 1967, BRIT J SOC CLIN PSYC, V6, P278, DOI [10.1111/j.2044-8260.1967.tb00530.x, DOI 10.1111/J.2044-8260.1967.TB00530.X]
[8]  
HOYER D, 1994, PHARMACOL REV, V46, P157
[9]   Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue [J].
Huang, YY ;
Grailhe, R ;
Arango, V ;
Hen, R ;
Mann, JJ .
NEUROPSYCHOPHARMACOLOGY, 1999, 21 (02) :238-246
[10]   Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism [J].
Huang, YY ;
Oquendo, MA ;
Friedman, JMH ;
Greenhill, LL ;
Brodsky, B ;
Malone, KM ;
Khait, V ;
Mann, JJ .
NEUROPSYCHOPHARMACOLOGY, 2003, 28 (01) :163-169