Ribosomal DNA and the Nucleolus as Keystones of Nuclear Architecture, Organization, and Function

被引:48
作者
Cerqueira, Amanda V. [1 ]
Lemos, Bernardo [1 ,2 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Program Mol & Integrat Physiol Sci, Boston, MA 02115 USA
[2] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
关键词
RNA-POLYMERASE-I; DENSE FIBRILLAR COMPONENTS; C-MYC AMPLIFICATION; INSITU HYBRIDIZATION; SITU HYBRIDIZATION; NONCODING RNA; N-MYC; RDNA; TRANSCRIPTION; CHROMATIN;
D O I
10.1016/j.tig.2019.07.011
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The multicopy ribosomal DNA (rDNA) array gives origin to the nucleolus, a large nonmembrane-bound organelle that occupies a substantial volume within the cell nucleus. The rDNA/nucleolus has emerged as a coordinating hub in which seemingly disparate cellular functions converge, and from which a variety of cellular and organismal phenotypes emerge. However, the role of the nucleolus as a determinant and organizer of nuclear architecture and other epigenetic states of the genome is not well understood. We discuss the role of rDNA and the nucleolus in nuclear organization and function - from nucleolus-associated domains (NADs) to the regulation of imprinted loci and X chromosome inactivation, as well as rDNA contact maps that anchor and position the rDNA relative to the rest of the genome. The influence of the nucleolus on nuclear organization undoubtedly modulates diverse biological processes from metabolism to cell proliferation, genome-wide gene expression, maintenance of epigenetic states, and aging.
引用
收藏
页码:710 / 723
页数:14
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