Genipin crosslinked microcapsules of gelatin A and κ-carrageenan polyelectrolyte complex for encapsulation of Neem (Azadirachta Indica A.Juss.) seed oil

被引:46
作者
Devi, Nirmala [1 ]
Maji, Tarun Kumar [1 ]
机构
[1] Tezpur Univ, Dept Chem Sci, Napaam 784028, India
关键词
Microcapsule; Gelatin; Carrageenan; Complex coacervation; Crosslinking; Characterisation; CONTROLLED-RELEASE; IN-VITRO; LINKING; CARBODIIMIDE; HYDROGELS; MICROENCAPSULATION; MICROSPHERES; MEMBRANE; MATRICES; COLLAGEN;
D O I
10.1007/s00289-010-0246-5
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Microcapsules containing neem seed oil (NSO) were prepared using complex coacervation technique and employing gelatin A and kappa-carrageenan polyelectrolyte complex. The yield of the coacervate was dependent on the ratio of the two polymers and on the pH of the medium. Viscosity and turbidity measurements were carried out in order to support the ratio of the two polymers that produced the highest yield. The encapsulation efficiency and the release rates of NSO were dependent on the amount of crosslinker, oil loading and polymer concentration. Scanning electron micrographs showed the formation of free flowing spherical microcapsules. The size of microcapsules increased with the increase of the concentration of the polymer. Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry study showed that there was no significant interaction between NSO and carrageenan-gelatin complex.
引用
收藏
页码:347 / 362
页数:16
相关论文
共 29 条
[1]   Cross-linked alginate-gelatine beads: a new matrix for controlled release of pindolol [J].
Almeida, PF ;
Almeida, AJ .
JOURNAL OF CONTROLLED RELEASE, 2004, 97 (03) :431-439
[2]  
Aminabhavi T. M., 1998, POLYM NEWS, V23, P246
[3]   Carrageenan-oligochitosan microcapsules: optimization of the formation process [J].
Bartkowiak, A ;
Hunkeler, D .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2001, 21 (04) :285-298
[4]   A genipin-crosslinked gelatin membrane as wound-dressing material:: in vitro and in vivo studies [J].
Chang, WH ;
Chang, Y ;
Lai, PH ;
Sung, HW .
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2003, 14 (05) :481-495
[5]   A review on controlled release of nitrogen fertilizers through polymeric membrane devices [J].
Dave, AM ;
Mehta, MH ;
Aminabhavi, TM ;
Kulkarni, AR ;
Soppimath, KS .
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING, 1999, 38 (04) :675-711
[6]   CROSS-LINKING OF GELATIN CAPSULES AND ITS RELEVANCE TO THEIR IN-VITRO IN-VIVO PERFORMANCE [J].
DIGENIS, GA ;
GOLD, TB ;
SHAH, VP .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (07) :915-921
[7]   Synthesis and physicochemical analysis of gelatin-based hydrogels for drug carrier matrices [J].
Einerson, NJ ;
Stevens, KR ;
Kao, WYJ .
BIOMATERIALS, 2003, 24 (03) :509-523
[8]  
ERRINGTON N, 1993, INT J BIOL MACROMOL, V15, P112
[9]   Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties [J].
Esposito, E ;
Cortesi, R ;
Nastruzzi, C .
BIOMATERIALS, 1996, 17 (20) :2009-2020
[10]   Biocompatibility studies of anionic collagen membranes with different degree of glutaraldehyde cross-linking [J].
Goissis, G ;
Junior, EM ;
Marcantônio, JAC ;
Lia, RCC ;
Cancian, DCJ ;
de Carvalho, M .
BIOMATERIALS, 1999, 20 (01) :27-34