Presence of sarcopenia in asthma-COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES) IV and V (2008-2011)

被引:19
作者
Lee, Dong-Won [1 ]
Jin, Hyun-Jung [2 ]
Shin, Kyeong-Cheol [2 ]
Chung, Jin-Hong [2 ]
Lee, Hyoung-Woo [3 ]
Lee, Kwan-Ho [2 ]
机构
[1] Andong Sungso Hosp, Dept Internal Med, Div Pulmonol, Andong, South Korea
[2] Yeungnam Univ Hosp, Dept Internal Med, Div Pulmonol & Allergy, 170 Hyunchung Ro, Daegu 42415, South Korea
[3] Yeungnam Univ Hosp, Dept Internal Med, Div Endocrinol, Daegu, South Korea
来源
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2017年 / 12卷
关键词
asthma; chronic obstructive pulmonary disease; asthma-COPD overlap syndrome; sarcopenia; bone-mineral density; OBSTRUCTIVE PULMONARY-DISEASE; SYSTEMIC INFLAMMATION; OLDER-ADULTS; MUSCLE MASS; OSTEOPOROSIS; MEN; MORTALITY; ASSOCIATION; PREVALENT; FRACTURE;
D O I
10.2147/COPD.S138497
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Sarcopenia and decreased bone-mineral density (BMD) are common in elderly people, and are major comorbidities of obstructive airway disease (OAD). However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma-COPD overlap syndrome (ACOS), is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Materials and methods: Among the research subjects in KNHANES IV and V (2008-2011), 5,562 were >= 50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. Results: In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (P, < 0.001 and P=0.017, respectively). The sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129-38.828 [P=0.036], OR 9.611, 95% CI 1.133-81.544 [P=0.038], and OR 6.935, 95% CI 1.194-40.272 [P=0.031], respectively). However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. Conclusion: In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes.
引用
收藏
页码:2355 / 2362
页数:8
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