The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

被引:43
作者
Xu, Tongfu [1 ]
Yang, Liu [2 ]
Yan, Cheng [2 ]
Wang, Xiaoxia [2 ]
Huang, Ping [2 ]
Zhao, Feng [2 ]
Zhao, Liyun [2 ,3 ]
Zhang, Mingliang [4 ]
Jia, Weiping [4 ]
Wang, Xiangdong [1 ]
Liu, Yong [2 ,5 ,6 ]
机构
[1] Shandong Univ, Sch Med, Dept Cell Biol, Jinan 250012, Shandong, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China
[3] China Novartis Inst BioMed Res, Shanghai 201203, Peoples R China
[4] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai 200233, Peoples R China
[5] Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
[6] Univ Chinese Acad Sci, Shanghai 201203, Peoples R China
关键词
ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; XBP1; D1;
D O I
10.1038/cr.2014.55
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:1137 / 1140
页数:4
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