Recent progress regarding kaempferol for the treatment of various diseases

被引：341
作者：
Ren, Jie [1 ,2 ]
Lu, Yifei [1 ,2 ]
Qian, Yanhong [1 ,2 ]
Chen, Bozhou [1 ,2 ]
Wu, Tao [1 ,2 ]
Ji, Guang [2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Ctr Chinese Med Therapy & Syst Biol, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Inst Digest Dis, Longhua Hosp, 725 Wan Ping Rd, Shanghai 200032, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2019年 / 18卷 / 04期
基金：
中国国家自然科学基金;
关键词：
kaempferol; inflammation; cancer; liver injury; obesity; diabetes; ACUTE LUNG INJURY; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; ACUTE PROMYELOCYTIC LEUKEMIA; TO-MESENCHYMAL TRANSITION; GROWTH-FACTOR RECEPTOR; INDUCED GASTRIC-ULCERS; INDUCED APOPTOSIS; OXIDATIVE STRESS; SIGNALING PATHWAYS;
D O I：
10.3892/etm.2019.7886
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Kaempferol, also known as kaempferol-3 or kaempferide, is a flavonoid compound that naturally occurs in tea, as well as numerous common vegetables and fruits, including beans, broccoli, cabbage, gooseberries, grapes, kale, strawberries, tomatoes, citrus fruits, brussel sprouts, apples and grapefruit. The present review mainly summarizes the application of kaempferol in treating diseases and the underlying mechanisms that are currently being studied. Due to its anti-inflammatory properties, it may be used to treat numerous acute and chronic inflammation-induced diseases, including intervertebral disc degeneration and colitis, as well as post-menopausal bone loss and acute lung injury. In addition, it has beneficial effects against cancer, liver injury, obesity and diabetes, inhibits vascular endothelial inflammation, protects the cranial nerve and heart function, and may be used for treating fibroproliferative disorders, including hypertrophic scar.
引用
收藏
页码：2759 / 2776
页数：18
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