Assessment of arterial stiffness in patients with chronic lower extremity venous disease: An observational study

被引:8
作者
Aykan, Ahmet Cagri [1 ]
Mentese, Seda [2 ]
Dogan, Emre [3 ]
Cavusoglu, Ismail Gokhan [4 ]
Aykan, Duygun Altintas [5 ]
Kalaycioglu, Ezgi [1 ]
Gokdeniz, Tayyar [1 ]
Mentese, Umit [3 ]
机构
[1] Ahi Evren Chest & Cardiovasc Surg Educ & Res Hosp, Dept Cardiol, TR-61040 Trabzon, Turkey
[2] Ankara Numune Training & Res Hosp, Dept Emergency Med, Trabzon, Turkey
[3] Ahi Evren Chest & Cardiovasc Surg Educ & Res Hosp, Dept Cardiovasc Surg, TR-61040 Trabzon, Turkey
[4] Ahi Evren Chest & Cardiovasc Surg Educ & Res Hosp, Dept Radiol, TR-61040 Trabzon, Turkey
[5] Karadeniz Tech Univ, Fac Med, Dept Pharmacol, Trabzon, Turkey
关键词
CAVI; arterial stiffness; chronic venous disease; insufficiency; varicose; vein; cardiac; ANKLE VASCULAR INDEX; EPICARDIAL FAT THICKNESS; INSUFFICIENCY; DYSFUNCTION; MECHANISMS; PREDICTION; EVENTS; VEINS; WALL;
D O I
10.1177/0268355515591394
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objectives Arterial stiffness is associated with major adverse cardiovascular events. Chronic venous insufficiency (CVI) is severe form of chronic venous disease (CVD). The aim of this study is to investigate arterial stiffness by cardio-ankle vascular index (CAVI) in patients with CVI. Methods This observational and cross-sectional study involved 87 subjects with CVI and 86 healthy subjects. All subjects underwent ultrasonography examination. CAVI was measured by VaSera-1000 CAVI instrument. Results High density lipoprotein cholesterol (HDL) was significantly lower in patients with CVI than controls (46.839.25mg/dl vs 51.33 +/- 11.13mg/dl, p=0.004). Body mass index (BMI) was significantly higher in CVI patients than controls (28.53 +/- 4.10kg/m(2) vs 26.37 +/- 5.16kg/m(2), p=0.003). Ankle brachial index (ABI) was significantly lower in patients with CVI compared to controls (1.08 +/- 0.08 vs 1.14 +/- 0.11, p<0.001). CAVI was significantly higher in patients with CVI than controls (7.94 +/- 1.37 vs 6.73 +/- 1.16, p<0.001). Mean arterial pressure (MAP) was significantly higher in patients with CVI than control group (105.41 +/- 10.77mmHg vs 99.70 +/- 11.17mmHg, p=0.001). CAVI (p<0.001, Odds ratio (OR)=2.033, 95% Confidence interval (CI)=1.493-2.768), ABI (p=0.003, OR=0.003, 95% CI=0.001-0.137), female sex (p<0.001, OR=3.949, 95% CI=1.613-9.663), and HDL (p<0.001, OR=0.923, 95% CI=0.883-0.964) were the independent predictors of CVI. A CAVI value>7.9 had a sensitivity 64.4% and a specificity of 94.7% for predicting the presence of CVI in ROC analysis (area under curve=0.791, 95% CI=0.723-0.849, p<0.001). Conclusion CAVI is independently increased in CVI patients. Therefore CVI may be accepted a form of vascular sclerosis and vascular system should be evaluated in continuum not isolated.
引用
收藏
页码:349 / 355
页数:7
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