A synthesis of captopril through a Baylis-Hillman reaction

被引：30

作者：

Feltrin, MP ^{[1
]}

Almeida, WP ^{[1
]}

机构：

[1] Univ Estadual Paulista, Inst Ciencias Saude, BR-13055044 Campinas, SP, Brazil

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1081/SCC-120017189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the antihipertensive amide 1, named captopril, is described. The strategy is based on a Baylis-Hillman reaction between N-acryloylproline and formaldehyde. Subsequential diastereoselective hydrogenation step and functional group interconversion provided captopril in good overall yield.

引用

页码：1141 / 1146

页数：6

共 9 条

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