[18F]Fluorination Optimisation and the Fully Automated Production of [18F]MEL050 Using a Microfluidic System

被引：6
作者：
Matesic, Lidia [1 ]
Kallinen, Annukka [1 ,2 ]
Wyatt, Naomi A. [1 ]
Pham, Tien Q. [1 ]
Greguric, Ivan [1 ,3 ]
Pascali, Giancarlo [1 ]
机构：
[1] Australian Nucl Sci & Technol Org, LifeSci Div, Kirrawee Dc, NSW 2232, Australia
[2] Univ Helsinki, Dept Chem, Lab Radiochem, Helsinki 00014, Finland
[3] Univ New S Wales, Sch Chem Engn, Australian Ctr Nanomed, Sydney, NSW 2052, Australia
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2015年 / 68卷 / 01期
关键词：
RENAL CLEARANCE; PET; TUMOR; RADIOSYNTHESIS;
D O I：
10.1071/CH14130
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The [F-18]radiolabelling of the melanin-targeting positron-emission tomography radiotracer [F-18]MEL050 was rapidly optimised using a commercial continuous-flow microfluidic system. The optimal [F-18]fluorination incorporation conditions were then translated to production-scale experiments (35-150 GBq) suitable for preclinical imaging, complete with automated HPLC-solid phase extraction purification and formulation. [F-18]MEL050 was obtained in 43 +/- 10% radiochemical yield in similar to 50min.
引用
收藏
页码：69 / 71
页数：3
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