Carbohydrate vaccines: developing sweet solutions to sticky situations?

被引：484
作者：
Astronomo, Rena D. [1 ]
Burton, Dennis R. [2 ,3 ]
机构：
[1] Scripps Res Inst, Neutralizing Antibody Ctr, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Neutralizing Antibody Ctr, Int AIDS Vaccine Initiat, La Jolla, CA 92037 USA
[3] Massachusetts Inst Technol & Harvard, Massachusetts Gen Hosp, Ragon Inst, Boston, MA 02114 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
INFLUENZAE TYPE-B; POLYSACCHARIDE CONJUGATE VACCINE; NEUTRALIZING ANTIBODY 2G12; CRYPTOCOCCUS-NEOFORMANS; MONOCLONAL-ANTIBODIES; GLYCOCONJUGATE VACCINES; CUTANEOUS LEISHMANIASIS; IMMUNOLOGICAL RESPONSE; ALTERED GLYCOSYLATION; CLINICAL-EVALUATION;
D O I：
10.1038/nrd3012
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer cells for vaccine purposes.
引用
收藏
页码：308 / 324
页数：17
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