Adipose tissue as an endocrine organ

被引：1135
作者：
Ahima, RS
Flier, JS
机构：
[1] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA
[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 08期
关键词：
D O I：
10.1016/S1043-2760(00)00301-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue. Leptin has profound effects on appetite and energy balance, and is also involved in the regulation of neuroendocrine and immune function. Sex steroid and glucocorticoid metabolism in adipose tissue has been implicated as a determinant of body fat distribution and cardiovascular risk. Other adipose products, for example, proinflammatory cytokines, complement factors and components of the coagulation/fibrinolytic cascade, may mediate the metabolic and cardiovascular complications associated with obesity.
引用
收藏
页码：327 / 332
页数：6
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