Understanding the development and function of T follicular helper cells

被引：85

作者：

Nurieva, Roza I. ^{[1
]}

Chung, Yeonseok ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2010年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

autoimmunity; Bcl6; costimulation; IL-21; T follicular helper (Tfh) cells; INTERFERON-REGULATORY FACTOR-4; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GERMINAL-CENTER FORMATION; CXC CHEMOKINE RECEPTOR-5; GENE-EXPRESSION PROGRAM; DEVELOPING TH1 CELLS; I INTERFERON; TRANSCRIPTION FACTOR; HUMORAL IMMUNITY; C-MAF;

D O I：

10.1038/cmi.2010.24

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A fundamental function of T helper (Th) cells is to regulate B-cell proliferation and immunoglobulin class switching, especially in the germinal centers. Th1 and Th2 lineages of CD4(+) T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a (IgG2a) and IgG1/IgE, respectively. Recently, it has become clear that a subset CD4(+) T cells, named T follicular helper (Tfh) cells, is critical to B-cell response induction. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4(+) T-cell lineages, and the role of Tfh cells in health and disease. Cellular & Molecular Immunology (2010) 7, 190-197; doi:10.1038/cmi.2010.24; published online 12 April 2010

引用

页码：190 / 197

页数：8

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