Repeated anti-N-methyl-D-aspartate receptor encephalitis coexisting with anti-myelin oligodendrocyte glycoprotein antibody-associated diseases: A case report

被引：16
作者：
Aoe, Shingo [1 ]
Kokudo, Yohei [1 ]
Takata, Tadayuki [2 ]
Kobara, Hideki [1 ]
Yamamoto, Mitsutoshi [3 ]
Touge, Tetsuo [4 ]
Deguchi, Kazushi [1 ]
Masaki, Tsutomu [1 ]
机构：
[1] Kagawa Univ, Dept Gastroenterol & Neurol, Fac Med, 1750-1 Ikenobe, Miki, Kagawa, Japan
[2] Kagawa Univ, Dept Gen Med, Fac Med, 1750-1 Ikenobe, Miki, Kagawa, Japan
[3] Takamatsu Neurol Clin, Dept Neurol, 4-10 Konya Machi, Takamatsu, Kagawa, Japan
[4] Kagawa Univ, Dept Hlth Sci, Fac Med, 1750-1 Ikenobe, Miki, Kagawa, Japan
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 35卷
基金：
日本学术振兴会;
关键词：
N-methyl-D-aspartate receptor; Myelin oligodendrocyte glycoprotein (MOG); Anti-MOG antibody; Ataxia; Word-finding difficulty; DIAGNOSIS;
D O I：
10.1016/j.msard.2019.08.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The coexistence of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated diseases has been reported. We report the case of a 36-year-old woman who presented with repeated typical anti-NMDAR encephalitis coexisting with unusual symptoms not consistent with anti-NMDAR encephalitis. Apart from the anti-NMDAR encephalitis, her first episode was characterized by balance disability with bilateral medial frontal cortical lesions, suggesting the involvement of the cortico-reticular projections and the basal ganglia-brainstem projections. The second episode presented with Broca's aphasia caused by involvement of the Broca's area and lower part of the precentral gyrus. The detection of MOG-Ab in both episodes suggested the coexistence of MOG-Ab-associated diseases. Thus, an evaluation of MOG-Ab should be considered when anti-NMDAR encephalitis presenting with atypical symptoms is encountered.
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收藏
页码：182 / 184
页数：3
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