Matrix Metalloproteinases 2 and 9 and their Tissue Inhibitors in the Follicular Fluid of Patients with Polycystic Ovaries Undergoing In Vitro Fertilisation

被引：3

作者：

Baka, Stavroula ^{[1
,2
]}

Zourla, Konstantina ^{[1
]}

Kouskouni, Evangelia ^{[1
]}

Makrakis, Evangelos ^{[3
]}

Demeridou, Stella ^{[1
]}

Tzanakaki, Despoina ^{[2
]}

Hassiakos, Dimitris ^{[2
]}

Creatsas, George ^{[2
]}

机构：

[1] Univ Athens, Aretaie Hosp, Dept Biopathol, GR-10679 Athens, Greece

[2] Univ Athens, Aretaie Hosp, Dept Assisted Reprod Unit, Dept Obstet & Gynecol 2, GR-10679 Athens, Greece

[3] Embryo ART, IVF Unit, Athens, Greece

来源：

IN VIVO | 2010年 / 24卷 / 03期

关键词：

Matrix metalloproteinases; tissue inhibitors of matrix metalloproteinases; follicular fluid; polycystic ovary syndrome; in vitro fertilisation; LUTEINIZED GRANULOSA-CELLS; WOMEN; EXPRESSION; MATRIX-METALLOPROTEINASE-9; AND-9;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study was undertaken to investigate the levels of matrix metalloproteinase (MMP)-2, MMP-9 and their tissue inhibitors (TIMP-2 and TIMP-1, respectively) in the follicular fluid of 39 patients with polycystic ovary syndrome (PCOS) and compare them with the levels found in 56 age- and weight-matched normally ovulating women, all undergoing in vitro fertilisation (IVF) treatment. Significantly higher levels of MMP-2 and MMP-9 (p=0.02 and p<0.001, respectively) as well as TIMP-2 and TIMP-1 (p=0.006 and p<0.001, respectively) were found in the PCOS group compared to controls. Women who achieved pregnancy had higher TIMP-1 levels compared to the non-pregnant ones in the control group (p=0.01). In conclusion, women with PCOS exhibited significantly increased gelatinolytic activity compared with controls of similar age and body mass index, thus indicating a more intense extracellular matrix remodelling in this group of patients during IVF treatment due to multiple follicular development and cyst formation.

引用

页码：291 / 294

页数：4

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