LncRNA: A link between RNA and cancer

被引：953
作者：
Yang, Guodong [1 ]
Lu, Xiaozhao [2 ]
Yuan, Lijun [3 ]
机构：
[1] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Peoples R China
[2] PLA, Hosp 323, Dept Nephrol, Xian 710054, Peoples R China
[3] Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound, Xian 710038, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2014年 / 1839卷 / 11期
基金：
美国国家科学基金会;
关键词：
Long non-coding RNAs; Cancer; Epigenetics; Transcriptional regulation; Posttranscriptional regulation; Cancer diagnosis and therapy; LONG NONCODING RNA; GENOME-WIDE ASSOCIATION; BECKWITH-WIEDEMANN-SYNDROME; PROSTATE-SPECIFIC GENE; TUMOR-SUPPRESSOR GENE; PROTEIN-CODING RNA; HEPATOCELLULAR-CARCINOMA; ANTISENSE TRANSCRIPT; POOR-PROGNOSIS; DIAGNOSTIC PERFORMANCE;
D O I：
10.1016/j.bbagrm.2014.08.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Unraveling the gene expression networks governing cancer initiation and development is essential while remains largely uncompleted. With the innovations in RNA-seq technologies and computational biology, long noncoding RNAs (lncRNAs) are being identified and characterized at a rapid pace. Recent findings reveal that IncRNAs are implicated in serial steps of cancer development. These IncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. Their misexpression confers the cancer cell capacities for tumor initiation, growth, and metastasis. The review here will emphasize their aberrant expression and function in cancer, and the roles in cancer diagnosis and therapy will be also discussed.(C) 2014 Published by Elsevier B.V.
引用
收藏
页码：1097 / 1109
页数：13
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