Immunohistochemical localization of leptin receptor in the rat brain

被引：193

作者：

Shioda, S ^{[1
]}

Funahashi, H

Nakajo, S

Yada, T

Maruta, O

Nakai, Y

机构：

[1] Showa Univ, Sch Med, Dept Anat, Tokyo 142, Japan

[2] Showa Univ, Sch Pharmaceut Sci, Biol Chem Lab, Tokyo 142, Japan

[3] Kagoshima Univ, Sch Med, Dept Physiol, Kagoshima 890, Japan

[4] Natl Inst Physiol Sci, Lab Intracellular Metab, Okazaki, Aichi 444, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 243卷 / 1-3期

关键词：

obesity; leptin receptor; immunohistochemistry; Western blotting; brain; rat;

D O I：

10.1016/S0304-3940(98)00082-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of leptin receptor in the rat brain was determined by immunocytochemistry and Western blotting. Strong leptin receptor immunoreactivity was detected in the arcuate, paraventricular and ventromedial nuclei of the hypothalamus, and lateral hypothalamic area. The olfactory bulb, neocortex, cerebellar cortex, dorsal raphe nucleus, inferior olive nucleus, nucleus of the solitary tract, dorsal motor nucleus of the vagus nerve also showed intense immunoreactivity. Western blotting analysis yielded a 120-kDa major band. (C) 1998 Elsevier Science Ireland Ltd.

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页码：41 / 44

页数：4

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