Immunohistochemical localization of leptin receptor in the rat brain

被引：190
|
作者：
Shioda, S [1 ]
Funahashi, H
Nakajo, S
Yada, T
Maruta, O
Nakai, Y
机构：
[1] Showa Univ, Sch Med, Dept Anat, Tokyo 142, Japan
[2] Showa Univ, Sch Pharmaceut Sci, Biol Chem Lab, Tokyo 142, Japan
[3] Kagoshima Univ, Sch Med, Dept Physiol, Kagoshima 890, Japan
[4] Natl Inst Physiol Sci, Lab Intracellular Metab, Okazaki, Aichi 444, Japan
来源：
NEUROSCIENCE LETTERS | 1998年 / 243卷 / 1-3期
关键词：
obesity; leptin receptor; immunohistochemistry; Western blotting; brain; rat;
D O I：
10.1016/S0304-3940(98)00082-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The distribution of leptin receptor in the rat brain was determined by immunocytochemistry and Western blotting. Strong leptin receptor immunoreactivity was detected in the arcuate, paraventricular and ventromedial nuclei of the hypothalamus, and lateral hypothalamic area. The olfactory bulb, neocortex, cerebellar cortex, dorsal raphe nucleus, inferior olive nucleus, nucleus of the solitary tract, dorsal motor nucleus of the vagus nerve also showed intense immunoreactivity. Western blotting analysis yielded a 120-kDa major band. (C) 1998 Elsevier Science Ireland Ltd.
引用
收藏
页码：41 / 44
页数：4
相关论文
共 50 条
  • [1] Immunohistochemical localization of leptin in rat kidney
    Martínez-Ansó, E
    Lostao, MP
    Martinez, JA
    KIDNEY INTERNATIONAL, 1999, 55 (03) : 1129 - 1130
  • [2] Immunohistochemical localization of the neural cannabinoid receptor in rat brain
    Pettit, DAD
    Harrison, MP
    Olson, JM
    Spencer, RF
    Cabral, GA
    JOURNAL OF NEUROSCIENCE RESEARCH, 1998, 51 (03) : 391 - 402
  • [3] Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain
    Yarnell, DO
    Knight, DS
    Hamilton, K
    Tulp, O
    Tso, P
    BRAIN RESEARCH, 1998, 785 (01) : 80 - 90
  • [4] In situ hybridization and immunohistochemical localization of leptin hormone and leptin receptor in the seminal vesicle and prostate gland of adult rat
    Sayed-Ahmed, Ahmed
    Abd-Elmaksoud, Ahmed
    Elnasharty, Mohamed
    Abu El-Magd, Mohamed
    ACTA HISTOCHEMICA, 2012, 114 (03) : 185 - 191
  • [5] Localization of leptin receptor in the human brain
    Couce, ME
    Burguera, B
    Parisi, JE
    Jensen, MD
    Lloyd, RV
    NEUROENDOCRINOLOGY, 1997, 66 (03) : 145 - 150
  • [6] Immunohistochemical localization of the somatostatin sst4 receptor in rat brain
    Selmer, IS
    Schindler, M
    Humphrey, PPA
    Emson, PC
    NEUROSCIENCE, 2000, 98 (03) : 523 - 533
  • [7] Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain
    Mütze, J
    Roth, J
    Gerstberger, M
    Matsumura, K
    Hübschle, T
    NEUROSCIENCE LETTERS, 2006, 394 (02) : 105 - 110
  • [8] Expression and immunohistochemical localization of leptin receptor in human periapical granuloma
    Martin-Gonzalez, J.
    Carmona-Fernandez, A.
    Perez-Perez, A.
    Sanchez-Jimenez, F.
    Sanchez-Margalet, V.
    Segura-Egea, J. J.
    INTERNATIONAL ENDODONTIC JOURNAL, 2015, 48 (06) : 611 - 618
  • [9] IMMUNOHISTOCHEMICAL LOCALIZATION OF GLUCOCORTICOID RECEPTOR IN RAT-BRAIN WITH MONOCLONAL-ANTIBODIES
    MCGIMSEY, WC
    SAR, M
    STUMPF, WE
    FEDERATION PROCEEDINGS, 1987, 46 (03) : 849 - 849
  • [10] Ultrastructural localization of the receptor for leptin in the rat hypothalamus
    Funahashi, H
    Ryushi, T
    Mizushima, H
    Katoh, S
    Shioda, S
    HORMONES AND BEHAVIOR, 2000, 37 (04) : 327 - 334
12345