Therapeutic potential of nanoceria in regenerative medicine

被引：42

作者：

Das, Soumen ^{[1
]}

Chigurupati, Srinivasulu ^{[2
]}

Dowding, Janet ^{[3
]}

Munusamy, Prabhakaran ^{[4
]}

Baer, Donald R. ^{[4
]}

McGinnis, James F. ^{[5
]}

Mattson, Mark P. ^{[6
]}

Self, William ^{[7
]}

Seal, Sudipta ^{[8
]}

机构：

[1] Univ Cent Florida, Nanosci Technol Ctr, Adv Mat Proc Anal Ctr, Orlando, FL 32816 USA

[2] US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res, Rockville, MD 20857 USA

[3] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32816 USA

[4] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA

[5] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Norman, OK 73019 USA

[6] NIA, Neurosci Lab, Intramural Res Program, Bethesda, MD 20892 USA

[7] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32816 USA

[8] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Nanosci & Technol Ctr, Coll Med, Orlando, FL 32816 USA

来源：

MRS BULLETIN | 2014年 / 39卷 / 11期

基金：

美国国家科学基金会;

关键词：

CERIUM OXIDE NANOPARTICLES; NEURONAL SURVIVAL; OXIDATIVE STRESS; PROTECT; CELLS; RADIATION; NANOSTRUCTURES; ANGIOGENESIS; APOPTOSIS; TOXICITY;

D O I：

10.1557/mrs.2014.221

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging, or trauma. Advancement of tissue engineering requires innovation in the field of three-dimensional scaffolding and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates that can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for an extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

引用

页码：976 / 983

页数：8

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