Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar:: G6PD Mahidol (487G>A) is the most common variant in the Myanmar population

被引：55
作者：
Matsuoka, H
Wang, JC
Hirai, M
Arai, M
Yoshida, S
Kobayashi, T
Jalloh, A
Lin, K
Kawamoto, F
机构：
[1] Jichi Med Sch, Dept Med Zool, Minami Kawachi, Tochigi 3290498, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Biomed Chem, Tokyo, Japan
[3] Nagoya Univ, Grad Sch Med, Dept Adv Med Sci, Showa Ku, Nagoya, Aichi, Japan
[4] Dept Med Res, Div Parasitol, Upper Myanmar, Myanmar
[5] Oita Univ, Fac Med, Inst Sci Res, Oita 87011, Japan
来源：
JOURNAL OF HUMAN GENETICS | 2004年 / 49卷 / 10期
关键词：
glucose-6-phosphate dehydrogenase deficiency; Mahidol; malaria; Myanmar; primaquine;
D O I：
10.1007/s10038-004-0187-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We conducted a survey of malaria diagnoses and treatments in remote areas of Myanmar. Blood specimens from more than 1,000 people were collected by the finger-prick method, and 121 (11%) of these people were found to be glucose-6-phosphate dehydrogenase (G6PD) deficient. Of these 121, 50 consented to analysis of the G6PD genome. We read the G6PD sequences of these subjects and found 45 cases of G6PD Mahidol (487G>A), two of G6PD Coimbra (592C>T), two of G6PD Union (1360C>T), and one of G6PD Canton (1376G>T). Taken together with data from our previous report, 91.3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations.
引用
收藏
页码：544 / 547
页数：4
相关论文
共 50 条
[41]   Tafenoquine and G6PD: a primer for clinicians [J].
Chu, Cindy S. ;
Freedman, David O. .
JOURNAL OF TRAVEL MEDICINE, 2019, 26 (04)
[42]   Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia [J].
Hiroyuki Matsuoka ;
Meiji Arai ;
Shigeto Yoshida ;
Indah Setyawati Tantular ;
Suhintam Pusarawati ;
Henyo Kerong ;
Fumihiko Kawamoto .
Journal of Human Genetics, 2003, 48 :541-544
[43]   Five different glucose-6-phophate dehydrogenase (G6PD) variants found among 11 G6PD-deficient persons in Flores Island, Indonesia [J].
Matsuoka, H ;
Arai, M ;
Yoshida, S ;
Tantular, IS ;
Pusarawati, S ;
Kerong, H ;
Kawamoto, F .
JOURNAL OF HUMAN GENETICS, 2003, 48 (10) :541-544
[44]   Acceptability and feasibility of glucose-6-phosphate dehydrogenase (G6PD) testing using SD Biosensor by village malaria workers in Cambodia: a qualitative study [J].
Cassidy-Seyoum, Sarah A. ;
Adhikari, Bipin ;
Chheng, Keoratha ;
Chanpheakdey, Phal ;
Meershoek, Agnes ;
Hsiang, Michelle S. ;
von Seidlein, Lorenz ;
Tripura, Rupam ;
Ley, Benedikt ;
Price, Ric N. ;
Dysoley, Lek ;
Thriemer, Kamala ;
Engel, Nora .
BMJ GLOBAL HEALTH, 2025, 10 (06)
[45]   Suitability of Capillary Blood for Quantitative Assessment of G6PD Activity and Performances of G6PD Point-of-Care Tests [J].
Bancone, Germana ;
Chu, Cindy S. ;
Chowwiwat, Nongnud ;
Somsakchaicharoen, Raweewan ;
Wilaisrisak, Pornpimon ;
Charunwatthana, Prakaykaew ;
Bansil, Pooja ;
McGray, Sarah ;
Domingo, Gonzalo J. ;
Nosten, Francois H. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 92 (04) :818-824
[46]   G6PD deficiency assessment in Freetown, Sierra Leone, reveals further insight into the molecular heterogeneity of G6PD A- [J].
Jalloh, Amadu ;
Jalloh, Muctarr ;
Gamanga, Idrissa ;
Baion, David ;
Sahr, Foday ;
Gbakima, Aiah ;
Willoughby, Victor R. ;
Matsuoka, Hiroyuki .
JOURNAL OF HUMAN GENETICS, 2008, 53 (07) :675-679
[47]   G6PD deficiency assessment in Freetown, Sierra Leone, reveals further insight into the molecular heterogeneity of G6PD A- [J].
Amadu Jalloh ;
Muctarr Jalloh ;
Idrissa Gamanga ;
David Baion ;
Foday Sahr ;
Aiah Gbakima ;
Victor R. Willoughby ;
Hiroyuki Matsuoka .
Journal of Human Genetics, 2008, 53 :675-679
[48]   Evaluating Percentage-Based Reporting of Glucose-6-Phosphate Dehydrogenase (G6PD) Enzymatic Activity: Assessment of Patient Eligibility for Malaria Prevention and Treatment With Tafenoquine [J].
Calvaresi, Emilia C. ;
Genzen, Jonathan R. .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2020, 154 (02) :248-254
[49]   Neutrophils and monocytes from subjects with the Mediterranean G6PD variant:: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production [J].
Mordmüller, B ;
Turrini, F ;
Long, H ;
Kremsner, PG ;
Arese, P .
EUROPEAN CYTOKINE NETWORK, 1998, 9 (03) :239-245
[50]   Plasmodium vivax Malaria and G6PD Testing [J].
Ley, Benedikt ;
Luzzatto, Lucio .
PATHOGENS, 2023, 12 (12)
12345