Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases

被引：31

作者：

Navarro-Nunez, Leyre ^{[1
]}

Lozano, Maria L. ^{[1
]}

Martinez, Constantino ^{[1
]}

Vicente, Vicente ^{[1
]}

Rivera, Jose ^{[1
]}

机构：

[1] Univ Murcia, Ctr Reg Hemodonac, Unit Haematol & Med Oncol, Murcia 30003, Spain

来源：

FITOTERAPIA | 2010年 / 81卷 / 02期

关键词：

Quercetin; Collagen; Fibrinogen; Platelet; Spreading; Kinase; CORONARY-HEART-DISEASE; TYROSINE KINASE; SIGNALING PATHWAY; PROTEIN-KINASES; FLAVONOIDS INHIBIT; ACTIVATION; PHARMACOKINETICS; COMPONENTS; 3-KINASE; ALPHA(2)BETA(1);

D O I：

10.1016/j.fitote.2009.08.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

alpha(2)beta(1) and alpha(IIb)beta(3) integrins, that support platelet adhesion to collagen and fibrinogen, respectively, share common signaling molecules. The effect of quercetin on platelet static adhesion to collagen and fibrinogen was assessed and correlated with its kinase inhibitory activity. Quercetin strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin or the combined use of adenosine diphosphate and thromboxane A(2) inhibitors abrogated platelet spreading on these surfaces to a similar extent. We suggest that the inhibitory effect of quercetin on platelet kinases blocks early signaling events preventing a complete platelet spreading. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：75 / 80

页数：6

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