Effect of glutamate and angiotensin II on whole cell currents and release of nitric oxide in the rat subfornical organ

被引：19

作者：

Schmid, HA ^{[1
]}

机构：

[1] Max Planck Inst Physiol & Clin Res, D-61231 Bad Nauheim, Germany

来源：

AMINO ACIDS | 1998年 / 14卷 / 1-3期

关键词：

angiotensin II; patch clamp; glutamate; NMDA; nitric oxide; thirst;

D O I：

10.1007/BF01345251

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated rat SFO-neurons showed that glutamate activates AngII-sensitive SFO-neurons by opening ligand-gated cation channels. An immunocytochemical study showed that activation of glutamate receptors increased the concentration of the inhibitory second messenger cGMP in the SFO. A model is proposed suggesting that NO protects SFO-neurons from overexcitability by excitatory neurotransmitters.

引用

页码：113 / 119

页数：7

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