Immunobiology of Long Noncoding RNAs

被引:361
作者
Atianand, Maninjay K. [1 ]
Caffrey, Daniel R. [1 ]
Fitzgerald, Katherine A. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Program Innate Immun, Div Infect Dis & Immunol,Dept Med, Worcester, MA 01605 USA
来源
ANNUAL REVIEW OF IMMUNOLOGY, VOL 35 | 2017年 / 35卷
关键词
noncoding RNA; lincRNA; lncRNA; immunity; gene regulation; TRANSCRIPTIONAL CONTROL; CELL-DIFFERENTIATION; DENDRITIC CELLS; CUTTING EDGE; XIST RNA; CHROMATIN; EXPRESSION; PROTEIN; GENE; ELEMENTS;
D O I
10.1146/annurev-immunol-041015-055459
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or proteins to promote or restrain the expression of protein-coding genes. Activation of immune cells is associated with dynamic changes in expression of genes, the products of which combat infectious microorganisms, initiate repair, and resolve inflammatory responses in cells and tissues. Recent evidence indicates that lncRNAs play important roles in directing the development of diverse immune cells and controlling the dynamic transcriptional programs that are a hallmark of immune cell activation. The importance of these molecules is underscored by their newly recognized roles in inflammatory diseases. In this review, we discuss the contribution of lncRNAs in the development and activation of immune cells and their roles in immune-related diseases. We also discuss challenges faced in identifying biological functions for this large and complex class of genes.
引用
收藏
页码:177 / 198
页数:22
相关论文
共 102 条
[1]   Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation [J].
Alvarez-Dominguez, Juan R. ;
Hu, Wenqian ;
Yuan, Bingbing ;
Shi, Jiahai ;
Park, Staphany S. ;
Gromatzky, Austin A. ;
van Oudenaarden, Alexander ;
Lodish, Harvey F. .
BLOOD, 2014, 123 (04) :570-581
[2]   A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation [J].
Atianand, Maninjay K. ;
Hu, Wenqian ;
Satpathy, Ansuman T. ;
Shen, Ying ;
Ricci, Emiliano P. ;
Alvarez-Dominguez, Juan R. ;
Bhatta, Ankit ;
Schattgen, Stefan A. ;
McGowan, Jason D. ;
Blin, Juliana ;
Braun, Joerg E. ;
Gandhi, Pallavi ;
Moore, Melissa J. ;
Chang, Howard Y. ;
Lodish, Harvey F. ;
Caffrey, Daniel R. ;
Fitzgerald, Katherine A. .
CELL, 2016, 165 (07) :1672-1685
[3]   Identification of a HoxA10 activation domain necessary for transcription of the gene encoding β3 integrin during myeloid differentiation [J].
Bei, Ling ;
Lu, YuFeng ;
Bellis, Susan L. ;
Zhou, Wei ;
Horvath, Elizabeth ;
Eklund, Elizabeth A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (23) :16846-16859
[4]   Antisense intergenic transcription in V(D)J recombination [J].
Bolland, DJ ;
Wood, AL ;
Johnston, CM ;
Bunting, SF ;
Morgan, G ;
Chakalova, L ;
Fraser, PJ ;
Corcoran, AE .
NATURE IMMUNOLOGY, 2004, 5 (06) :630-637
[5]   De novo transcriptome profiling of highly purified human lymphocytes primary cells [J].
Bonnal, Raoul J. P. ;
Ranzani, Valeria ;
Arrigoni, Alberto ;
Curti, Serena ;
Panzeri, Ilaria ;
Gruarin, Paola ;
Abrignani, Sergio ;
Rossetti, Grazisa ;
Pagani, Massimiliano .
SCIENTIFIC DATA, 2015, 2
[6]   Long noncoding RNAs in B-cell development and activation [J].
Brazao, Tiago F. ;
Johnson, Jethro S. ;
Muller, Jennifer ;
Heger, Andreas ;
Ponting, Chris P. ;
Tybulewicz, Victor L. J. .
BLOOD, 2016, 128 (07) :E10-E19
[7]   A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs [J].
Broadbent, Kate M. ;
Park, Daniel ;
Wolf, Ashley R. ;
Van Tyne, Daria ;
Sims, Jennifer S. ;
Ribacke, Ulf ;
Volkman, Sarah ;
Duraisingh, Manoj ;
Wirth, Dyann ;
Sabeti, Pardis C. ;
Rinn, John L. .
GENOME BIOLOGY, 2011, 12 (06)
[8]  
Buenrostro JD, 2013, NAT METHODS, V10, P1213, DOI [10.1038/NMETH.2688, 10.1038/nmeth.2688]
[9]   Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat [J].
Carrieri, Claudia ;
Cimatti, Laura ;
Biagioli, Marta ;
Beugnet, Anne ;
Zucchelli, Silvia ;
Fedele, Stefania ;
Pesce, Elisa ;
Ferrer, Isidre ;
Collavin, Licio ;
Santoro, Claudio ;
Forrest, Alistair R. R. ;
Carninci, Piero ;
Biffo, Stefano ;
Stupka, Elia ;
Gustincich, Stefano .
NATURE, 2012, 491 (7424) :454-+
[10]   A long noncoding RNA associated with susceptibility to celiac disease [J].
Castellanos-Rubio, Ainara ;
Fernandez-Jimenez, Nora ;
Kratchmarov, Radomir ;
Luo, Xiaobing ;
Bhagat, Govind ;
Green, Peter H. R. ;
Schneider, Robert ;
Kiledjian, Megerditch ;
Bilbao, Jose Ramon ;
Ghosh, Sankar .
SCIENCE, 2016, 352 (6281) :91-95