Neuroprotective and anti-dementia role of Tongqiao Huoxue decoction in rats with vascular dementia

被引：1

作者：

Lu, Changjun ^{[1
]}

Dun, Linglu ^{[1
]}

Liu, Guocheng ^{[1
]}

Lei, Xiaocui ^{[1
]}

Wei, Bingxin ^{[1
]}

An, Hongwei ^{[1
]}

Zhou, Zheyi ^{[1
]}

Wu, Yufen ^{[1
]}

Lu, Junlei ^{[1
]}

Zeng, Jianyuan ^{[1
]}

机构：

[1] Guangxi Univ Chinese Med, Affiliated Hosp 3, Dept Neurol, Liuzhou Tradit Chinese Med Hosp, Liuzhou 545001, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Vascular; Tongqiaohuoxue decoction; neuroprotective effects; oxidative stress; morris water maze; OXIDATIVE STRESS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: Tongqiaohuoxue decoction (TQHXD) as a traditional Chinese medicine has the role of promoting blood circulation, and vascular dementia (VD) is a cognitive dysfunction syndrome caused by cerebral embolism. This study investigated the protective effects of TQHXD on memory impairment and brain damage in rat. Methods: Morphological changes in ischemic brains were performed for hematoxylin-eosin (HE) staining. The number of apoptotic neurons was detected by TUNEL staining. Administration with TQHXD for 4 weeks significantly improved the behavioral performance of rats with vascular dementia, as showed in the Morris water maze test. Superoxide dismutase (SOD), Glutathione peroxidase (GSH-PX), malondialdehyde (MDA) were determined by spectrophotometry using commercial kits. Results: TQHXD enhanced activities of SOD and GSH-PX but it decreased their MDA content. Conclusion: These results demonstrated TQHXD possesses neuroprotective and antidementia properties and suggested that TQHXD might be developed as an effective drug for the prevention of VD.

引用

页码：3197 / 3202

页数：6

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