Neuroprotective and anti-dementia role of Tongqiao Huoxue decoction in rats with vascular dementia

被引：1

作者：

Lu, Changjun ^{[1
]}

Dun, Linglu ^{[1
]}

Liu, Guocheng ^{[1
]}

Lei, Xiaocui ^{[1
]}

Wei, Bingxin ^{[1
]}

An, Hongwei ^{[1
]}

Zhou, Zheyi ^{[1
]}

Wu, Yufen ^{[1
]}

Lu, Junlei ^{[1
]}

Zeng, Jianyuan ^{[1
]}

机构：

[1] Guangxi Univ Chinese Med, Affiliated Hosp 3, Dept Neurol, Liuzhou Tradit Chinese Med Hosp, Liuzhou 545001, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Vascular; Tongqiaohuoxue decoction; neuroprotective effects; oxidative stress; morris water maze; OXIDATIVE STRESS;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: Tongqiaohuoxue decoction (TQHXD) as a traditional Chinese medicine has the role of promoting blood circulation, and vascular dementia (VD) is a cognitive dysfunction syndrome caused by cerebral embolism. This study investigated the protective effects of TQHXD on memory impairment and brain damage in rat. Methods: Morphological changes in ischemic brains were performed for hematoxylin-eosin (HE) staining. The number of apoptotic neurons was detected by TUNEL staining. Administration with TQHXD for 4 weeks significantly improved the behavioral performance of rats with vascular dementia, as showed in the Morris water maze test. Superoxide dismutase (SOD), Glutathione peroxidase (GSH-PX), malondialdehyde (MDA) were determined by spectrophotometry using commercial kits. Results: TQHXD enhanced activities of SOD and GSH-PX but it decreased their MDA content. Conclusion: These results demonstrated TQHXD possesses neuroprotective and antidementia properties and suggested that TQHXD might be developed as an effective drug for the prevention of VD.

引用

页码：3197 / 3202

页数：6

共 50 条

[21] Persistence and Dose Escalation of Anti-dementia Medications
Brewer, Linda
Bennett, Kathleen
Williams, David
IRISH JOURNAL OF MEDICAL SCIENCE, 2012, 181 : S222 - S222
[22] Persistence and Dose Escalation of Anti-Dementia Medications
Brewer, Linda
Bennett, Kathleen
Williams, David
IRISH JOURNAL OF MEDICAL SCIENCE, 2012, 181 : S258 - S259
[23] Allocation ethical considerations as example of the anti-dementia
Helmchen, Hanfried
NERVENARZT, 2007, 78 : 404 - 404
[24] Anti-dementia effect of salvianolic acid B
Zhang, Juntian
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 : 246P - 246P
[25] Drug Therapy for Patients with Alzheimer's Dementia using Anti-dementia Drugs
Hausner, Lucrezia
Froelich, Lutz
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2019, 144 (03) : 152 - 156
[26] The different dimensions of dementia. Which expectations of anti-dementia therapy are realistic?
Satzger-Harsch, U
NERVENHEILKUNDE, 2005, 24 (02) : 149 - 150
[27] ANTI-DEMENTIA DRUG USE AMONG INDIVIDUALS WITHOUT A DOCUMENTED DEMENTIA DIAGNOSIS
Crawford, Teyrra
Hanna, Maya
Perfetto, Eleanor
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY, 2018, 14 (05): : E6 - E7
[28] PRESCRIPTION PATTERNS OF ANTI-DEMENTIA AND PSYCHOTROPIC DRUGS IN PEOPLE LIVING WITH DEMENTIA IN CHINA
Zhang Yingyang
Luo, Hao
Wong, Gloria H. Y.
Lum, Terry Y. S.
Chui, Celine
Wong, Ian C. K.
Wang, Huali
INNOVATION IN AGING, 2021, 5 : 646 - 646
[29] Neuroprotective Effect of Zishen Huoxue Decoction treatment on Vascular Dementia by activating PINK1/Parkin mediated Mitophagy in the Hippocampal CA1 Region
Zhao, Ziting
Xie, Le
Shi, Jiayi
Liu, Tonghe
Wang, Shiliang
Huang, Jianhua
Wu, Dahua
Zhang, Xiuli
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 319
[30] Neuroprotective Role of Klotho on Dementia
Ananya, Fariha Noor
Ahammed, Md Ripon
Lahori, Simmy
Parikh, Charmy
Lawrence, Jannel A.
Sulachni, F. N. U.
Barqawi, Tawfiq
Kamwal, Chhaya
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (06)

← 1 2 3 4 5 →